Armadillo repeat-containing protein 10

UniProt data

UniProt name: ARM10_HUMAN (Q8N2F6)

Gene name: ARMC10; Synonyms=SVH; ORFNames=PSEC0198

Organism: Homo sapiens (Human).

Function: May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. {ECO:0000269|PubMed:12839973, ECO:0000269|PubMed:17904127}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12839973}; Single-pass membrane protein {ECO:0000269|PubMed:12839973}.

Transmembrane domains:

  1. 5-27, 23 AA, Helical. {ECO:0000255}.

Sequence: 343 AA

10 20 30 40 50 60 MGGPRGAGWV AAGLLLGAGA CYCIYRLTRG RRRGDRELGI RSSKSAGALE EGTSEGQLCG 70 80 90 100 110 120 RSARPQTGGT WESQWSKTSQ PEDLTDGSYD DVLNAEQLQK LLYLLESTED PVIIERALIT 130 140 150 160 170 180 LGNNAAFSVN QAIIRELGGI PIVANKINHS NQSIKEKALN ALNNLSVNVE NQIKIKIYIS 190 200 210 220 230 240 QVCEDVFSGP LNSAVQLAGL TLLTNMTVTN DHQHMLHSYI TDLFQVLLTG NGNTKVQVLK 250 260 270 280 290 300 LLLNLSENPA MTEGLLRAQV DSSFLSLYDS HVAKEILLRV LTLFQNIKNC LKIEGHLAVQ 310 320 330 340 PTFTEGSLFF LLHGEECAQK IRALVDHHDA EVKEKVVTII PKI

CATM prediction

The sequence of ARM10_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          10        20        3
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 GGARGAGWVAAGLLLGAGACYCIYRLTRG 6.9 -40.0° 5.1 43.8 -41.6
Model 2 GGARGAGWVAAGLLLGAGACYCIYRLTRG 6.6 -47.0° 1.3 44.8 -38.2
Model 3 GGARGAGWVAAGLLLGAGACYCIYRLTRG 7.3 -51.0° 0.2 44.7 -21.3
Model 4 GGARGAGWVAAGLLLGAGACYCIYRLTRG 7.2 -51.0° 3.2 48.4 -17.5
Model 5 GGARGAGWVAAGLLLGAGACYCIYRLTRG 7.2 -43.0° 4.5 35.0 -1.5
Prolines* GGPRGAGWVAAGLLLGAGACYCIYRLTRG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 13, GLY, HA1 A, 10, VAL, O 3.15Å
B, 14, LEU, HA A, 13, GLY, O 2.74Å
B, 17, GLY, HA1 A, 14, LEU, O 3.24Å
B, 22, TYR, HA A, 25, TYR, OH 2.97Å
A, 13, GLY, HA1 B, 10, VAL, O 3.15Å
A, 14, LEU, HA B, 13, GLY, O 2.74Å
A, 17, GLY, HA1 B, 14, LEU, O 3.24Å