Protein GAPT

UniProt data

UniProt name: GAPT_HUMAN (Q8N292)

Gene name: GAPT; Synonyms=C5orf29

Organism: Homo sapiens (Human).

Function: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:18559951}; Single-pass membrane protein {ECO:0000269|PubMed:18559951}.

Transmembrane domains:

  1. 11-31, 21 AA, Helical. {ECO:0000255}.

Sequence: 157 AA

10 20 30 40 50 60 MSKSCGNNLA AISVGISLLL LLVVCGIGCV WHWKHRVATR FTLPRFLQRR SSRRKVCTKT 70 80 90 100 110 120 FLGPRIIGLR HEISVETQDH KSAVRGNNTH DNYENVEAGP PKAKGKTDKE LYENTGQSNF 130 140 150 EEHIYGNETS SDYYNFQKPR PSEVPQDEDI YILPDSY

CATM prediction

The sequence of GAPT_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    10        20        30   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 NLAAISVGISLLLLLVVCGIGCVWHWK 7.3 -47.1° 2.3 44.8 -12.0
Model 2 NLAAISVGISLLLLLVVCGIGCVWHWK 7.2 -55.0° 2.4 48.1 -1.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 25, CYS, HA A, 24, VAL, O 3.40Å
B, 28, GLY, HA1 A, 25, CYS, O 3.23Å
A, 25, CYS, HA B, 24, VAL, O 3.40Å
A, 28, GLY, HA1 B, 25, CYS, O 3.23Å