Porimin

UniProt data

UniProt name: PORIM_HUMAN (Q8N131)

Gene name: TMEM123; Synonyms=KCT3; ORFNames=PSEC0111, UNQ641/PRO1271

Organism: Homo sapiens (Human).

Function: Implicated in oncotic cell death, characterized by cell swelling, organelle swelling, vacuolization and increased membrane permeability. {ECO:0000269|PubMed:11481458}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 167-187, 21 AA, Helical. {ECO:0000255}.

Sequence: 208 AA

10 20 30 40 50 60 MGLGARGAWA ALLLGTLQVL ALLGAAHESA AMAASANIEN SGLPHNSSAN STETLQHVPS 70 80 90 100 110 120 DHTNETSNST VKPPTSVASD SSNTTVTTMK PTAASNTTTP GMVSTNMTST TLKSTPKTTS 130 140 150 160 170 180 VSQNTSQIST STMTVTHNSS VTSAASSVTI TTTMHSEAKK GSKFDTGSFV GGIVLTLGVL 190 200 SILYIGCKMY YSRRGIRYRT IDEHDAII

CATM prediction

The sequence of PORIM_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        170       180       1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 FDTGSFVGGIVLTLGVLSILYIGCKMY 7.3 -54.0° 2.9 50.5 -17.6
Model 2 FDTGSFVGGIVLTLGVLSILYIGCKMY 6.9 -51.8° 5.2 40.4 -1.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 169, PHE, HA A, 168, SER, O 3.29Å
B, 172, GLY, HA1 A, 169, PHE, O 3.16Å
B, 173, ILE, HA A, 176, THR, OG1 2.69Å
A, 169, PHE, HA B, 168, SER, O 3.29Å
A, 172, GLY, HA1 B, 169, PHE, O 3.16Å
A, 173, ILE, HA B, 176, THR, OG1 2.69Å