Cell adhesion molecule 3

UniProt data

UniProt name: CADM3_HUMAN (Q8N126)

Gene name: CADM3; Synonyms=IGSF4B, NECL1, SYNCAM3, TSLL1

Organism: Homo sapiens (Human).

Function: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, NECTIN1 and NECTIN3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q99N28}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99N28}. Cell junction {ECO:0000250|UniProtKB:Q99N28}.

Transmembrane domains:

  1. 331-351, 21 AA, Helical. {ECO:0000255}.

Sequence: 398 AA

10 20 30 40 50 60 MGAPAASLLL LLLLFACCWA PGGANLSQDD SQPWTSDETV VAGGTVVLKC QVKDHEDSSL 70 80 90 100 110 120 QWSNPAQQTL YFGEKRALRD NRIQLVTSTP HELSISISNV ALADEGEYTC SIFTMPVRTA 130 140 150 160 170 180 KSLVTVLGIP QKPIITGYKS SLREKDTATL NCQSSGSKPA ARLTWRKGDQ ELHGEPTRIQ 190 200 210 220 230 240 EDPNGKTFTV SSSVTFQVTR EDDGASIVCS VNHESLKGAD RSTSQRIEVL YTPTAMIRPD 250 260 270 280 290 300 PPHPREGQKL LLHCEGRGNP VPQQYLWEKE GSVPPLKMTQ ESALIFPFLN KSDSGTYGCT 310 320 330 340 350 360 ATSNMGSYKA YYTLNVNDPS PVPSSSSTYH AIIGGIVAFI VFLLLIMLIF LGHYLIRHKG 370 380 390 TYLTHEAKGS DDAPDADTAI INAEGGQSGG DDKKEYFI

CATM prediction

The sequence of CADM3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    330       340       350  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 TYHAIIGGIVAFIVFLLLIMLIFLGHY 6.4 -45.7° 3.6 37.1 -31.9
Model 2 TYHAIIGGIVAFIVFLLLIMLIFLGHY 7.3 -54.0° 3.6 49.1 -21.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 334, GLY, HA1 A, 331, ALA, O 2.41Å
B, 335, GLY, HA2 A, 334, GLY, O 3.16Å
A, 334, GLY, HA1 B, 331, ALA, O 2.41Å
A, 335, GLY, HA2 B, 334, GLY, O 3.16Å