Protein shisa-5

UniProt data

UniProt name: SHSA5_HUMAN (Q8N114)

Gene name: SHISA5; Synonyms=SCOTIN; ORFNames=PSEC0133

Organism: Homo sapiens (Human).

Function: Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. {ECO:0000269|PubMed:12135983}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12135983}; Single-pass type I membrane protein {ECO:0000269|PubMed:12135983}. Nucleus membrane {ECO:0000269|PubMed:12135983}.

Transmembrane domains:

  1. 106-126, 21 AA, Helical. {ECO:0000255}.

Sequence: 240 AA

10 20 30 40 50 60 MTAPVPAPRI LLPLLLLLLL TPPPGARGEV CMASRGLSLF PESCPDFCCG TCDDQYCCSD 70 80 90 100 110 120 VLKKFVWSEE RCAVPEASVP ASVEPVEQLG SALRFRPGYN DPMSGFGATL AVGLTIFVLS 130 140 150 160 170 180 VVTIIICFTC SCCCLYKTCR RPRPVVTTTT STTVVHAPYP QPPSVPPSYP GPSYQGYHTM 190 200 210 220 230 PPQPGMPAAP YPMQYPPPYP AQPMGPPAYH ETLAGGAAAP YPASQPPYNP AYMDAPKAAL

CATM prediction

The sequence of SHSA5_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         110       120       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 MSGFGATLAVGLTIFVLSVVTIIICFT 6.5 -47.0° 2.2 45.0 -13.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 108, ALA, HA A, 107, GLY, O 3.05Å
A, 108, ALA, HA B, 107, GLY, O 3.05Å