Killer cell immunoglobulin-like receptor 2DL5A

UniProt data

UniProt name: KI2LA_HUMAN (Q8N109)

Gene name: KIR2DL5A; Synonyms=CD158F, CD158F1, KIR2DL5

Organism: Homo sapiens (Human).

Function: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 375 AA

10 20 30 40 50 60 MSLMVISMAC VGFFLLQGAW THEGGQDKPL LSAWPSAVVP RGGHVTLLCR SRLGFTIFSL 70 80 90 100 110 120 YKEDGVPVPE LYNKIFWKSI LMGPVTPAHA GTYRCRGSHP RSPIEWSAPS NPLVIVVTGL 130 140 150 160 170 180 FGKPSLSAQP GPTVRTGENV TLSCSSRSSF DMYHLSREGR AHEPRLPAVP SVNGTFQADF 190 200 210 220 230 240 PLGPATHGGT YTCFGSLHDS PYEWSDPSDP LLVSVTGNSS SSSSSPTEPS SKTGIRRHLH 250 260 270 280 290 300 ILIGTSVAII LFIILFFFLL HCCCSNKKNA AVMDQEPAGD RTVNREDSDD QDPQEVTYAQ 310 320 330 340 350 360 LDHCVFTQTK ITSPSQRPKT PPTDTTMYME LPNAKPRSLS PAHKHHSQAL RGSSRETTAL 370 SQNRVASSHV PAAGI

CATM prediction

The sequence of KI2LA_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 RRHLHILIGTSVAIILFIILFFFLLHC 7.1 -49.0° 1.8 45.2 -33.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 241, ILE, HA A, 240, HSE, O 3.40Å
B, 244, GLY, HA1 A, 241, ILE, O 3.11Å
A, 241, ILE, HA B, 240, HSE, O 3.40Å
A, 244, GLY, HA1 B, 241, ILE, O 3.11Å