Kin of IRRE-like protein 3

UniProt data

UniProt name: KIRR3_HUMAN (Q8IZU9)

Gene name: KIRREL3 {ECO:0000312|HGNC:HGNC:23204}

Organism: Homo sapiens (Human).

Function: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target- specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250|UniProtKB:Q8BR86}.

Subcellular location: Processed kin of IRRE-like protein 3: Secreted {ECO:0000250|UniProtKB:Q8BR86}.

Transmembrane domains:

  1. 536-556, 21 AA, Helical. {ECO:0000255}.

Sequence: 778 AA

10 20 30 40 50 60 MKPFQLDLLF VCFFLFSQEL GLQKRGCCLV LGYMAKDKFR RMNEGQVYSF SQQPQDQVVV 70 80 90 100 110 120 SGQPVTLLCA IPEYDGFVLW IKDGLALGVG RDLSSYPQYL VVGNHLSGEH HLKILRAELQ 130 140 150 160 170 180 DDAVYECQAI QAAIRSRPAR LTVLVPPDDP VILGGPVISL RAGDPLNLTC HADNAKPAAS 190 200 210 220 230 240 IIWLRKGEVI NGATYSKTLL RDGKRESIVS TLFISPGDVE NGQSIVCRAT NKAIPGGKET 250 260 270 280 290 300 SVTIDIQHPP LVNLSVEPQP VLEDNVVTFH CSAKANPAVT QYRWAKRGQI IKEASGEVYR 310 320 330 340 350 360 TTVDYTYFSE PVSCEVTNAL GSTNLSRTVD VYFGPRMTTE PQSLLVDLGS DAIFSCAWTG 370 380 390 400 410 420 NPSLTIVWMK RGSGVVLSNE KTLTLKSVRQ EDAGKYVCRA VVPRVGAGER EVTLTVNGPP 430 440 450 460 470 480 IISSTQTQHA LHGEKGQIKC FIRSTPPPDR IAWSWKENVL ESGTSGRYTV ETISTEEGVI 490 500 510 520 530 540 STLTISNIVR ADFQTIYNCT AWNSFGSDTE IIRLKEQGSE MKSGAGLEAE SVPMAVIIGV 550 560 570 580 590 600 AVGAGVAFLV LMATIVAFCC ARSQRNLKGV VSAKNDIRVE IVHKEPASGR EGEEHSTIKQ 610 620 630 640 650 660 LMMDRGEFQQ DSVLKQLEVL KEEEKEFQNL KDPTNGYYSV NTFKEHHSTP TISLSSCQPD 670 680 690 700 710 720 LRPAGKQRVP TGMSFTNIYS TLSGQGRLYD YGQRFVLGMG SSSIELCERE FQRGSLSDSS 730 740 750 760 770 SFLDTQCDSS VSSSGKQDGY VQFDKASKAS ASSSHHSQSS SQNSDPSRPL QRRMQTHV

CATM prediction

The sequence of KIRR3_HUMAN returned 6 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         540       550       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 AMAVIIGVAVGAGVAFLVLMATIVAFC 6.4 -45.7° 4.3 55.1 -33.2
Model 2 AMAVIIGVAVGAGVAFLVLMATIVAFC 7.2 -51.0° 1.2 45.4 -20.0
Model 3 AMAVIIGVAVGAGVAFLVLMATIVAFC 7.3 -36.2° 1.5 36.2 -17.8
Model 4 AMAVIIGVAVGAGVAFLVLMATIVAFC 7.2 -55.1° 0.3 44.8 -16.5
Model 5 AMAVIIGVAVGAGVAFLVLMATIVAFC 7.1 -50.0° 2.9 47.0 -12.4
Model 6 AMAVIIGVAVGAGVAFLVLMATIVAFC 7.2 -35.0° 3.8 53.0 -2.3
Prolines* PMAVIIGVAVGAGVAFLVLMATIVAFC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 539, GLY, HA1 A, 536, VAL, O 3.19Å
B, 540, VAL, HA A, 539, GLY, O 2.37Å
B, 543, GLY, HA1 A, 540, VAL, O 2.81Å
A, 539, GLY, HA1 B, 536, VAL, O 3.19Å
A, 540, VAL, HA B, 539, GLY, O 2.37Å
A, 543, GLY, HA1 B, 540, VAL, O 2.81Å