C-type lectin-like domain family 1

UniProt data

UniProt name: CLCL1_HUMAN (Q8IZS7)

Gene name: CLECL1; Synonyms=DCAL1

Organism: Homo sapiens (Human).

Function: May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. {ECO:0000269|PubMed:12421943}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12421943}; Single-pass type II membrane protein {ECO:0000269|PubMed:12421943}.

Transmembrane domains:

  1. 68-88, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 167 AA

10 20 30 40 50 60 MVSNFFHVIQ VFEKSATLIS KTEHIGFVIY SWRKSTTHLG SRRKFAISIY LSEVSLQKYD 70 80 90 100 110 120 CPFSGTSFVV FSLFLICAMA GDVVYADIKT VRTSPLELAF PLQRSVSFNF STVHKSCPAK 130 140 150 160 DWKVHKGKCY WIAETKKSWN KSQNDCAINN SYLMVIQDIT AMVRFNI

CATM prediction

The sequence of CLCL1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       70        80        90
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 GTSFVVFSLFLICAMAGDVVYADIKTV 7.1 -50.3° 2.9 46.6 -21.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 78, ALA, HA A, 77, CYS, O 3.14Å
B, 81, GLY, HA1 A, 78, ALA, O 3.10Å
A, 78, ALA, HA B, 77, CYS, O 3.14Å
A, 81, GLY, HA1 B, 78, ALA, O 3.10Å