Tomoregulin-1

UniProt data

UniProt name: TEFF1_HUMAN (Q8IYR6)

Gene name: TMEFF1; Synonyms=C9orf2

Organism: Homo sapiens (Human).

Function: May inhibit NODAL and BMP signaling during neural patterning (By similarity). May be a tumor suppressor in brain cancers. {ECO:0000250, ECO:0000269|PubMed:12743596}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12743596}; Single-pass type I membrane protein {ECO:0000269|PubMed:12743596}.

Transmembrane domains:

  1. 331-351, 21 AA, Helical. {ECO:0000255}.

Sequence: 380 AA

10 20 30 40 50 60 MGAAAAEAPL RLPAAPPLAF CCYTSVLLLF AFSLPGSRAS NQPPGGGGGS GGDCPGGKGK 70 80 90 100 110 120 SINCSELNVR ESDVRVCDES SCKYGGVCKE DGDGLKCACQ FQCHTNYIPV CGSNGDTYQN 130 140 150 160 170 180 ECFLRRAACK HQKEITVIAR GPCYSDNGSG SGEGEEEGSG AEVHRKHSKC GPCKYKAECD 190 200 210 220 230 240 EDAENVGCVC NIDCSGYSFN PVCASDGSSY NNPCFVREAS CIKQEQIDIR HLGHCTDTDD 250 260 270 280 290 300 TSLLGKKDDG LQYRPDVKDA SDQREDVYIG NHMPCPENLN GYCIHGKCEF IYSTQKASCR 310 320 330 340 350 360 CESGYTGQHC EKTDFSILYV VPSRQKLTHV LIAAIIGAVQ IAIIVAIVMC ITRKCPKNNR 370 GRRQKQNLGH FTSDTSSRMV

CATM prediction

The sequence of TEFF1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    330       340       350  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 THVLIAAIIGAVQIAIIVAIVMCITRK 7.1 -43.3° 4.5 35.0 -14.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 334, ALA, HA A, 333, ALA, O 3.09Å
B, 337, GLY, HA1 A, 334, ALA, O 3.29Å
A, 334, ALA, HA B, 333, ALA, O 3.09Å
A, 337, GLY, HA1 B, 334, ALA, O 3.29Å