Neuropathy target esterase

UniProt data

UniProt name: PLPL6_HUMAN (Q8IY17)

Gene name: PNPLA6; Synonyms=NTE

Organism: Homo sapiens (Human).

Function: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000269|PubMed:15044461, ECO:0000269|PubMed:1666291}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15044461}; Single-pass type I membrane protein {ECO:0000269|PubMed:15044461}; Cytoplasmic side {ECO:0000269|PubMed:15044461}. Note=Anchored to the cytoplasmic face of the endoplasmic reticulum by its N-terminal transmembrane segment. {ECO:0000269|PubMed:15044461}.

Transmembrane domains:

  1. 51-71, 21 AA, Helical. {ECO:0000255}.

Sequence: 1366 AA

10 20 30 40 50 60 MGTSSHGLAT NSSGAKVAER DGFQDVLAPG EGSAGRICGA QPVPFVPQVL GVMIGAGVAV 70 80 90 100 110 120 VVTAVLILLV VRRLRVPKTP APDGPRYRFR KRDKVLFYGR KIMRKVSQST SSLVDTSVSA 130 140 150 160 170 180 TSRPRMRKKL KMLNIAKKIL RIQKETPTLQ RKEPPPAVLE ADLTEGDLAN SHLPSEVLYM 190 200 210 220 230 240 LKNVRVLGHF EKPLFLELCR HMVFQRLGQG DYVFRPGQPD ASIYVVQDGL LELCLPGPDG 250 260 270 280 290 300 KECVVKEVVP GDSVNSLLSI LDVITGHQHP QRTVSARAAR DSTVLRLPVE AFSAVFTKYP 310 320 330 340 350 360 ESLVRVVQII MVRLQRVTFL ALHNYLGLTN ELFSHEIQPL RLFPSPGLPT RTSPVRGSKR 370 380 390 400 410 420 MVSTSATDEP RETPGRPPDP TGAPLPGPTG DPVKPTSLET PSAPLLSRCV SMPGDISGLQ 430 440 450 460 470 480 GGPRSDFDMA YERGRISVSL QEEASGGSLA APARTPTQEP REQPAGACEY SYCEDESATG 490 500 510 520 530 540 GCPFGPYQGR QTSSIFEAAK QELAKLMRIE DPSLLNSRVL LHHAKAGTII ARQGDQDVSL 550 560 570 580 590 600 HFVLWGCLHV YQRMIDKAED VCLFVAQPGE LVGQLAVLTG EPLIFTLRAQ RDCTFLRISK 610 620 630 640 650 660 SDFYEIMRAQ PSVVLSAAHT VAARMSPFVR QMDFAIDWTA VEAGRALYRQ GDRSDCTYIV 670 680 690 700 710 720 LNGRLRSVIQ RGSGKKELVG EYGRGDLIGV VEALTRQPRA TTVHAVRDTE LAKLPEGTLG 730 740 750 760 770 780 HIKRRYPQVV TRLIHLLSQK ILGNLQQLQG PFPAGSGLGV PPHSELTNPA SNLATVAILP 790 800 810 820 830 840 VCAEVPMVAF TLELQHALQA IGPTLLLNSD IIRARLGASA LDSIQEFRLS GWLAQQEDAH 850 860 870 880 890 900 RIVLYQTDAS LTPWTVRCLR QADCILIVGL GDQEPTLGQL EQMLENTAVR ALKQLVLLHR 910 920 930 940 950 960 EEGAGPTRTV EWLNMRSWCS GHLHLRCPRR LFSRRSPAKL HELYEKVFSR RADRHSDFSR 970 980 990 1000 1010 1020 LARVLTGNTI ALVLGGGGAR GCSHIGVLKA LEEAGVPVDL VGGTSIGSFI GALYAEERSA 1030 1040 1050 1060 1070 1080 SRTKQRAREW AKSMTSVLEP VLDLTYPVTS MFTGSAFNRS IHRVFQDKQI EDLWLPYFNV 1090 1100 1110 1120 1130 1140 TTDITASAMR VHKDGSLWRY VRASMTLSGY LPPLCDPKDG HLLMDGGYIN NLPADIARSM 1150 1160 1170 1180 1190 1200 GAKTVIAIDV GSQDETDLST YGDSLSGWWL LWKRLNPWAD KVKVPDMAEI QSRLAYVSCV 1210 1220 1230 1240 1250 1260 RQLEVVKSSS YCEYLRPPID CFKTMDFGKF DQIYDVGYQY GKAVFGGWSR GNVIEKMLTD 1270 1280 1290 1300 1310 1320 RRSTDLNESR RADVLAFPSS GFTDLAEIVS RIEPPTSYVS DGCADGEESD CLTEYEEDAG 1330 1340 1350 1360 PDCSRDEGGS PEGASPSTAS EMEEEKSILR QRRCLPQEPP GSATDA

CATM prediction

The sequence of PLPL6_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    50        60        70   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 QVLGVMIGAGVAVVVTAVLILLVVRRL 6.4 -47.1° 4.8 55.4 -15.6
Model 2 QVLGVMIGAGVAVVVTAVLILLVVRRL 6.7 -47.0° 1.4 44.8 -13.7
Model 3 QVLGVMIGAGVAVVVTAVLILLVVRRL 7.3 -27.0° 6.0 58.0 -8.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 52, VAL, HA A, 51, GLY, O 2.34Å
B, 55, GLY, HA1 A, 52, VAL, O 2.96Å
A, 52, VAL, HA B, 51, GLY, O 2.34Å
A, 55, GLY, HA1 B, 52, VAL, O 2.96Å