Mitochondrial Rho GTPase 1

UniProt data

UniProt name: MIRO1_HUMAN (Q8IXI2)

Gene name: RHOT1; Synonyms=ARHT1

Organism: Homo sapiens (Human).

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Transmembrane domains:

  1. 593-615, 23 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 618 AA

10 20 30 40 50 60 MKKDVRILLV GEPRVGKTSL IMSLVSEEFP EEVPPRAEEI TIPADVTPER VPTHIVDYSE 70 80 90 100 110 120 AEQSDEQLHQ EISQANVICI VYAVNNKHSI DKVTSRWIPL INERTDKDSR LPLILVGNKS 130 140 150 160 170 180 DLVEYSSMET ILPIMNQYTE IETCVECSAK NLKNISELFY YAQKAVLHPT GPLYCPEEKE 190 200 210 220 230 240 MKPACIKALT RIFKISDQDN DGTLNDAELN FFQRICFNTP LAPQALEDVK NVVRKHISDG 250 260 270 280 290 300 VADSGLTLKG FLFLHTLFIQ RGRHETTWTV LRRFGYDDDL DLTPEYLFPL LKIPPDCTTE 310 320 330 340 350 360 LNHHAYLFLQ STFDKHDLDR DCALSPDELK DLFKVFPYIP WGPDVNNTVC TNERGWITYQ 370 380 390 400 410 420 GFLSQWTLTT YLDVQRCLEY LGYLGYSILT EQESQASAVT VTRDKKIDLQ KKQTQRNVFR 430 440 450 460 470 480 CNVIGVKNCG KSGVLQALLG RNLMRQKKIR EDHKSYYAIN TVYVYGQEKY LLLHDISESE 490 500 510 520 530 540 FLTEAEIICD VVCLVYDVSN PKSFEYCARI FKQHFMDSRI PCLIVAAKSD LHEVKQEYSI 550 560 570 580 590 600 SPTDFCRKHK MPPPQAFTCN TADAPSKDIF VKLTTMAMYP HVTQADLKSS TFWLRASFGA 610 TVFAVLGFAM YKALLKQR

CATM prediction

The sequence of MIRO1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  590       600       610      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 STFWLRASFGATVFAVLGFAMYKALLKQR 6.8 -48.9° 2.8 32.0 -15.8
Model 2 STFWLRASFGATVFAVLGFAMYKALLKQR 7.4 -54.0° 2.8 51.3 -4.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 596, ALA, HA A, 595, ARG, O 3.06Å
B, 599, GLY, HA1 A, 596, ALA, O 2.88Å
A, 596, ALA, HA B, 595, ARG, O 3.06Å
A, 599, GLY, HA1 B, 596, ALA, O 2.88Å
A, 611, TYR, HH B, 611, TYR, OH 2.01Å