Mitochondrial Rho GTPase 2

UniProt data

UniProt name: MIRO2_HUMAN (Q8IXI1)

Gene name: RHOT2; Synonyms=ARHT2, C16orf39

Organism: Homo sapiens (Human).

Function: Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). {ECO:0000250, ECO:0000269|PubMed:16630562}.

Subcellular location: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.

Transmembrane domains:

  1. 593-615, 23 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 618 AA

10 20 30 40 50 60 MRRDVRILLL GEAQVGKTSL ILSLVGEEFP EEVPPRAEEI TIPADVTPEK VPTHIVDYSE 70 80 90 100 110 120 AEQTDEELRE EIHKANVVCV VYDVSEEATI EKIRTKWIPL VNGGTTQGPR VPIILVGNKS 130 140 150 160 170 180 DLRSGSSMEA VLPIMSQFPE IETCVECSAK NLRNISELFY YAQKAVLHPT APLYDPEAKQ 190 200 210 220 230 240 LRPACAQALT RIFRLSDQDL DQALSDEELN AFQKSCFGHP LAPQALEDVK TVVCRNVAGG 250 260 270 280 290 300 VREDRLTLDG FLFLNTLFIQ RGRHETTWTI LRRFGYSDAL ELTADYLSPL IHVPPGCSTE 310 320 330 340 350 360 LNHLGYQFVQ RVFEKHDQDR DGALSPVELQ SLFSVFPAAP WGPELPRTVR TEAGRLPLHG 370 380 390 400 410 420 YLCQWTLVTY LDVRSCLGHL GYLGYPTLCE QDQAHAITVT REKRLDQEKG QTQRSVLLCK 430 440 450 460 470 480 VVGARGVGKS AFLQAFLGRG LGHQDTREQP PGYAIDTVQV NGQEKYLILC EVGTDGLLAT 490 500 510 520 530 540 SLDATCDVAC LMFDGSDPKS FAHCASVYKH HYMDGQTPCL FVSSKADLPE GVAVSGPSPA 550 560 570 580 590 600 EFCRKHRLPA PVPFSCAGPA EPSTTIFTQL ATMAAFPHLV HAELHPSSFW LRGLLGVVGA 610 AVAAVLSFSL YRVLVKSQ

CATM prediction

The sequence of MIRO2_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  590       600       610      
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 WLRGLLGVVGAAVAAVLSFSLYRVLVKSQ 7.0 -43.0° 4.5 34.9 -18.8
Model 2 WLRGLLGVVGAAVAAVLSFSLYRVLVKSQ 7.4 -32.9° 2.2 35.1 -12.7
Model 3 WLRGLLGVVGAAVAAVLSFSLYRVLVKSQ 6.9 -35.3° 4.9 35.8 -11.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 596, GLY, HA1 A, 593, GLY, O 2.75Å
B, 597, VAL, HA A, 596, GLY, O 3.41Å
A, 596, GLY, HA1 B, 593, GLY, O 2.75Å
A, 597, VAL, HA B, 596, GLY, O 3.41Å