Cadherin-like protein 26

UniProt data

UniProt name: CAD26_HUMAN (Q8IXH8)

Gene name: CDH26

Organism: Homo sapiens (Human).

Function: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 615-635, 21 AA, Helical. {ECO:0000255}.

Sequence: 852 AA

10 20 30 40 50 60 MAMRSGRHPS LLLLLVLLLW LLQVSIIDSV QQETDDLTKQ TKEKIYQPLR RSKRRWVITT 70 80 90 100 110 120 LELEEEDPGP FPKLIGELFN NMSYNMSLMY LISGPGVDEY PEIGLFSLED HENGRIYVHR 130 140 150 160 170 180 PVDREMTPSF TVYFDVVERS TGKIVDTSLI FNIRISDVND HAPQFPEKEF NITVQENQSA 190 200 210 220 230 240 GQPIFQMLAV DLDEENTPNS QVLYFLISQT PLLKESGFRV DRLSGEIRLS GCLDYETAPQ 250 260 270 280 290 300 FTLLIRARDC GEPSLSSTTT VHVDVQEGNN HRPAFTQENY KVQIPEGRAS QGVLRLLVQD 310 320 330 340 350 360 RDSPFTSAWR AKFNILHGNE EGHFDISTDP ETNEGILNVI KPLDYETRPA QSLIIVVENE 370 380 390 400 410 420 ERLVFCERGK LQPPRKAAAS ATVSVQVTDA NDPPAFHPQS FIVNKEEGAR PGTLLGTFNA 430 440 450 460 470 480 MDPDSQIRYE LVHDPANWVS VDKNSGVVIT VEPIDRESPH VNNSFYVIII HAVDDGFPPQ 490 500 510 520 530 540 TATGTLMLFL SDINDNVPTL RPRSRYMEVC ESAVHEPLHI EAEDPDLEPF SDPFTFELDN 550 560 570 580 590 600 TWGNAEDTWK LGRNWGQSVE LLTLRSLPRG NYLVPLFIGD KQGLSQKQTV HVRICPCASG 610 620 630 640 650 660 LTCVELADAE VGLHVGALFP VCAAFVALAV ALLFLLRCYF VLEPKRHGCS VSNDEGHQTL 670 680 690 700 710 720 VMYNAESKGT SAQTWSDVEG QRPALLICTA AAGPTQGVKA YPDATMHRQL LAPVEGRMAE 730 740 750 760 770 780 TLNQSKERNR FSLSRGCIIP QGRATAGRGL PQDIYKEMMP RRLTQTGKRK HGALARTPSF 790 800 810 820 830 840 KKVVYDHKED EENKAGRKQR SHLFKVMQLR NEQGGVRVQS AHSPSPLNKK ACFPGDYRGE 850 SAGGHNCRAV SG

CATM prediction

The sequence of CAD26_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          620       630      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GLHVGALFAVCAAFVALAVALLFLLRC 7.2 -37.1° 2.2 36.1 -10.9
Model 2 GLHVGALFAVCAAFVALAVALLFLLRC 7.2 -37.0° 2.2 36.0 -8.9
Model 3 GLHVGALFAVCAAFVALAVALLFLLRC 7.3 -36.0° 1.5 36.0 -7.5
Model 4 GLHVGALFAVCAAFVALAVALLFLLRC 6.8 -39.0° 6.0 45.0 -2.7
Prolines* GLHVGALFPVCAAFVALAVALLFLLRC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 620, ALA, HA A, 619, PHE, O 3.48Å
B, 624, ALA, HA A, 623, ALA, O 3.44Å
A, 620, ALA, HA B, 619, PHE, O 3.48Å
A, 624, ALA, HA B, 623, ALA, O 3.44Å