CD302 antigen

UniProt data

UniProt name: CD302_HUMAN (Q8IX05)

Gene name: CD302; Synonyms=CLEC13A, DCL1, KIAA0022

Organism: Homo sapiens (Human).

Function: Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration. {ECO:0000269|PubMed:17947679}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, filopodium {ECO:0000269|PubMed:17947679}. Cytoplasm, cell cortex {ECO:0000269|PubMed:17947679}. Cell projection, microvillus {ECO:0000269|PubMed:17947679}. Note=Colocalizes with F-actin in filopodia, cellular cortex and microvilli of the apical cell surface.

Transmembrane domains:

  1. 169-189, 21 AA, Helical. {ECO:0000255}.

Sequence: 232 AA

10 20 30 40 50 60 MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE DVRNQCTDHG 70 80 90 100 110 120 ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA SFKWFDNSNM TFDKWTDQDD 130 140 150 160 170 180 DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG TLCKTAIPYK RKYLSDNHIL ISALVIASTV 190 200 210 220 230 ILTVLGAIIW FLYKKHSDSR FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD

CATM prediction

The sequence of CD302_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      170       180       190
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 DNHILISALVIASTVILTVLGAIIWFL 6.8 -53.3° 1.9 45.0 -22.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 183, THR, HA A, 182, LEU, O 3.16Å
B, 186, GLY, HA1 A, 183, THR, O 2.73Å
B, 187, ALA, HA A, 186, GLY, O 3.38Å
A, 183, THR, HA B, 182, LEU, O 3.16Å
A, 186, GLY, HA1 B, 183, THR, O 2.73Å
A, 187, ALA, HA B, 186, GLY, O 3.38Å