Sodium channel subunit beta-4

UniProt data

UniProt name: SCN4B_HUMAN (Q8IWT1)

Gene name: SCN4B

Organism: Homo sapiens (Human).

Function: Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the suceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. {ECO:0000269|PubMed:24297919}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:24297919}; Single-pass type I membrane protein {ECO:0000269|PubMed:24297919}.

Transmembrane domains:

  1. 163-183, 21 AA, Helical. {ECO:0000255}.

Sequence: 228 AA

10 20 30 40 50 60 MPGAGDGGKA PARWLGTGLL GLFLLPVTLS LEVSVGKATD IYAVNGTEIL LPCTFSSCFG 70 80 90 100 110 120 FEDLHFRWTY NSSDAFKILI EGTVKNEKSD PKVTLKDDDR ITLVGSTKEK MNNISIVLRD 130 140 150 160 170 180 LEFSDTGKYT CHVKNPKENN LQHHATIFLQ VVDRLEEVDN TVTLIILAVV GGVIGLLILI 190 200 210 220 LLIKKLIIFI LKKTREKKKE CLVSSSGNDN TENGLPGSKA EEKPPSKV

CATM prediction

The sequence of SCN4B_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  160       170       180    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 NTVTLIILAVVGGVIGLLILILLIKKL 6.4 -55.0° 5.8 47.2 -20.3
Model 2 NTVTLIILAVVGGVIGLLILILLIKKL 7.2 -55.2° 2.4 47.9 -4.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 171, GLY, HA1 A, 168, ALA, O 2.73Å
B, 172, GLY, HA2 A, 171, GLY, O 2.52Å
B, 175, GLY, HA1 A, 172, GLY, O 3.37Å
A, 171, GLY, HA1 B, 168, ALA, O 2.73Å
A, 172, GLY, HA2 B, 171, GLY, O 2.52Å
A, 175, GLY, HA1 B, 172, GLY, O 3.37Å