Synaptotagmin-12

UniProt data

UniProt name: SYT12_HUMAN (Q8IV01)

Gene name: SYT12

Organism: Homo sapiens (Human).

Function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. {ECO:0000250}.

Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 19-39, 21 AA, Helical. {ECO:0000255}.

Sequence: 421 AA

10 20 30 40 50 60 MAVDVAEYHL SVIKSPPGWE VGVYAAGALA LLGIAAVSLW KLWTSGSFPS PSPFPNYDYR 70 80 90 100 110 120 YLQQKYGESC AEAREKRVPA WNAQRASTRG PPSRKGSLSI EDTFESISEL GPLELMGREL 130 140 150 160 170 180 DLAPYGTLRK SQSADSLNSI SSVSNTFGQD FTLGQVEVSM EYDTASHTLN VAVMQGKDLL 190 200 210 220 230 240 EREEASFESC FMRVSLLPDE QIVGISRIQR NAYSIFFDEK FSIPLDPTAL EEKSLRFSVF 250 260 270 280 290 300 GIDEDERNVS TGVVELKLSV LDLPLQPFSG WLYLQDQNKA ADAVGEILLS LSYLPTAERL 310 320 330 340 350 360 TVVVVKAKNL IWTNDKTTAD PFVKVYLLQD GRKMSKKKTA VKRDDPNPVF NEAMIFSVPA 370 380 390 400 410 420 IVLQDLSLRV TVAESSSDGR GDNVGHVIIG PSASGMGTTH WNQMLATLRR PVSMWHAVRR N

CATM prediction

The sequence of SYT12_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      20        30        40 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 AAGWEVGVYAAGALALLGIAAVSLWKL 6.7 -39.0° 6.0 45.0 -3.6
Prolines* PPGWEVGVYAAGALALLGIAAVSLWKL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 22, GLY, HA1 A, 19, TRP, O 3.27Å
A, 22, GLY, HA1 B, 19, TRP, O 3.27Å