Interferon lambda receptor 1

UniProt data

UniProt name: INLR1_HUMAN (Q8IU57)

Gene name: IFNLR1; Synonyms=IL28RA, LICR2

Organism: Homo sapiens (Human).

Function: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 229-249, 21 AA, Helical. {ECO:0000255}.

Sequence: 520 AA

10 20 30 40 50 60 MAGPERWGPL LLCLLQAAPG RPRLAPPQNV TLLSQNFSVY LTWLPGLGNP QDVTYFVAYQ 70 80 90 100 110 120 SSPTRRRWRE VEECAGTKEL LCSMMCLKKQ DLYNKFKGRV RTVSPSSKSP WVESEYLDYL 130 140 150 160 170 180 FEVEPAPPVL VLTQTEEILS ANATYQLPPC MPPLDLKYEV AFWKEGAGNK TLFPVTPHGQ 190 200 210 220 230 240 PVQITLQPAA SEHHCLSART IYTFSVPKYS KFSKPTCFLL EVPEANWAFL VLPSLLILLL 250 260 270 280 290 300 VIAAGGVIWK TLMGNPWFQR AKMPRALDFS GHTHPVATFQ PSRPESVNDL FLCPQKELTR 310 320 330 340 350 360 GVRPTPRVRA PATQQTRWKK DLAEDEEEED EEDTEDGVSF QPYIEPPSFL GQEHQAPGHS 370 380 390 400 410 420 EAGGVDSGRP RAPLVPSEGS SAWDSSDRSW ASTVDSSWDR AGSSGYLAEK GPGQGPGGDG 430 440 450 460 470 480 HQESLPPPEF SKDSGFLEEL PEDNLSSWAT WGTLPPEPNL VPGGPPVSLQ TLTFCWESSP 490 500 510 EEEEEARESE IEDSDAGSWG AESTQRTEDR GRTLGHYMAR

CATM prediction

The sequence of INLR1_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      230       240       250
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 NWAFLVLASLLILLLVIAAGGVIWKTL 7.2 -55.2° 0.9 50.0 -25.8
Model 2 NWAFLVLASLLILLLVIAAGGVIWKTL 7.3 -47.0° 2.2 45.2 -8.9
Prolines* NWAFLVLPSLLILLLVIAAGGVIWKTL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 245, GLY, HA1 A, 242, ILE, O 3.23Å
B, 246, GLY, HA2 A, 245, GLY, O 3.47Å
A, 245, GLY, HA1 B, 242, ILE, O 3.23Å
A, 246, GLY, HA2 B, 245, GLY, O 3.47Å