Trem-like transcript 1 protein

UniProt data

UniProt name: TRML1_HUMAN (Q86YW5)

Gene name: TREML1; Synonyms=TLT1; ORFNames=UNQ1825/PRO3438

Organism: Homo sapiens (Human).

Function: Cell surface receptor that may play a role in the innate and adaptive immune response. {ECO:0000269|PubMed:15128762}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15100151}; Single-pass type I membrane protein {ECO:0000269|PubMed:15100151}. Cytoplasm {ECO:0000269|PubMed:15100151}. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).

Transmembrane domains:

  1. 163-183, 21 AA, Helical. {ECO:0000255}.

Sequence: 311 AA

10 20 30 40 50 60 MGLTLLLLLL LGLEGQGIVG SLPEVLQAPV GSSILVQCHY RLQDVKAQKV WCRFLPEGCQ 70 80 90 100 110 120 PLVSSAVDRR APAGRRTFLT DLGGGLLQVE MVTLQEEDAG EYGCMVDGAR GPQILHRVSL 130 140 150 160 170 180 NILPPEEEEE THKIGSLAEN AFSDPAGSAN PLEPSQDEKS IPLIWGAVLL VGLLVAAVVL 190 200 210 220 230 240 FAVMAKRKQG NRLGVCGRFL SSRVSGMNPS SVVHHVSDSG PAAELPLDVP HIRLDSPPSF 250 260 270 280 290 300 DNTTYTSLPL DSPSGKPSLP APSSLPPLPP KVLVCSKPVT YATVIFPGGN KGGGTSCGPA 310 QNPPNNQTPS S

CATM prediction

The sequence of TRML1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  160       170       180    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 SIALIWGAVLLVGLLVAAVVLFAVMAK 7.5 -46.1° 2.7 46.8 -9.0
Prolines* SIPLIWGAVLLVGLLVAAVVLFAVMAK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 169, LEU, HA A, 168, VAL, O 3.46Å
B, 172, GLY, HA1 A, 169, LEU, O 3.42Å
A, 169, LEU, HA B, 168, VAL, O 3.46Å
A, 172, GLY, HA1 B, 169, LEU, O 3.42Å