Junctional adhesion molecule-like {ECO:0000312|HGNC:HGNC:19084}

UniProt data

UniProt name: JAML_HUMAN (Q86YT9)

Gene name: JAML {ECO:0000312|HGNC:HGNC:19084}; Synonyms=AMICA1

Organism: Homo sapiens (Human).

Function: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:12869515, ECO:0000269|PubMed:15800062, ECO:0000269|PubMed:18948633, ECO:0000269|PubMed:19064666}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12869515}; Single-pass type I membrane protein {ECO:0000269|PubMed:12869515}. Cell junction {ECO:0000269|PubMed:12869515}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).

Transmembrane domains:

  1. 276-296, 21 AA, Helical. {ECO:0000255}.

Sequence: 394 AA

10 20 30 40 50 60 MFCPLKLILL PVLLDYSLGL NDLNVSPPEL TVHVGDSALM GCVFQSTEDK CIFKIDWTLS 70 80 90 100 110 120 PGEHAKDEYV LYYYSNLSVP IGRFQNRVHL MGDILCNDGS LLLQDVQEAD QGTYICEIRL 130 140 150 160 170 180 KGESQVFKKA VVLHVLPEEP KELMVHVGGL IQMGCVFQST EVKHVTKVEW IFSGRRAKEE 190 200 210 220 230 240 IVFRYYHKLR MSVEYSQSWG HFQNRVNLVG DIFRNDGSIM LQGVRESDGG NYTCSIHLGN 250 260 270 280 290 300 LVFKKTIVLH VSPEEPRTLV TPAALRPLVL GGNQLVIIVG IVCATILLLP VLILIVKKTC 310 320 330 340 350 360 GNKSSVNSTV LVKNTKKTNP EIKEKPCHFE RCEGEKHIYS PIIVREVIEE EEPSEKSEAT 370 380 390 YMTMHPVWPS LRSDRNNSLE KKSGGGMPKT QQAF

CATM prediction

The sequence of JAML_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         280       290       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 NQLVIIVGIVCATILLLAVLILIVKKT 7.2 -55.3° 0.9 50.0 -3.6
Prolines* NQLVIIVGIVCATILLLPVLILIVKKT          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 280, GLY, HA1 A, 277, ILE, O 3.26Å
B, 281, ILE, HA A, 280, GLY, O 3.46Å
A, 280, GLY, HA1 B, 277, ILE, O 3.26Å
A, 281, ILE, HA B, 280, GLY, O 3.46Å