Podoplanin

UniProt data

UniProt name: PDPN_HUMAN (Q86YL7)

Gene name: PDPN {ECO:0000312|EMBL:AAH14668.2}

Organism: Homo sapiens (Human).

Function: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. {ECO:0000250|UniProtKB:Q62011, ECO:0000269|PubMed:14522983, ECO:0000269|PubMed:15231832, ECO:0000269|PubMed:15515019, ECO:0000269|PubMed:9651190}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, filopodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, microvillus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Localized to actin-rich microvilli and plasma membrane projections such as filopodia, lamellipodia and ruffles. {ECO:0000250}.

Transmembrane domains:

  1. 132-152, 21 AA, Helical. {ECO:0000255}.

Sequence: 162 AA

10 20 30 40 50 60 MWKVSALLFV LGSASLWVLA EGASTGQPED DTETTGLEGG VAMPGAEDDV VTPGTSEDRY 70 80 90 100 110 120 KSGLTTLVAT SVNSVTGIRI EDLPTSESTV HAQEQSPSAT ASNVATSHST EKVDGDTQTT 130 140 150 160 VEKDGLSTVT LVGIIVGVLL AIGFIGAIIV VVMRKMSGRY SP

CATM prediction

The sequence of PDPN_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   130       140       150   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.1 -50.7° 2.4 45.4 -33.5
Model 2 VTLVGIIVGVLLAIGFIGAIIVVVMRK 6.5 -43.4° 4.9 58.1 -30.1
Model 3 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.4 -48.0° 0.4 47.0 -17.2
Model 4 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.3 -43.0° 3.0 35.1 -8.6
Model 5 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.4 -54.0° 3.6 35.1 -4.3
Model 6 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.4 -25.0° 1.2 49.0 -4.0
Model 7 VTLVGIIVGVLLAIGFIGAIIVVVMRK 7.0 -55.0° 0.9 50.0 -3.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 134, ILE, HA A, 133, GLY, O 3.19Å
B, 137, GLY, HA1 A, 134, ILE, O 2.79Å
B, 138, VAL, HA A, 137, GLY, O 3.19Å
A, 134, ILE, HA B, 133, GLY, O 3.19Å
A, 137, GLY, HA1 B, 134, ILE, O 2.79Å
A, 138, VAL, HA B, 137, GLY, O 3.19Å