Low-density lipoprotein receptor class A domain-containing protein 3

UniProt data

UniProt name: LRAD3_HUMAN (Q86YD5)

Gene name: LDLRAD3

Organism: Homo sapiens (Human).

Function: May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 174-194, 21 AA, Helical. {ECO:0000255}.

Sequence: 345 AA

10 20 30 40 50 60 MWLLGPLCLL LSSAAESQLL PGNNFTNECN IPGNFMCSNG RCIPGAWQCD GLPDCFDKSD 70 80 90 100 110 120 EKECPKAKSK CGPTFFPCAS GIHCIIGRFR CNGFEDCPDG SDEENCTANP LLCSTARYHC 130 140 150 160 170 180 KNGLCIDKSF ICDGQNNCQD NSDEESCESS QEPGSGQVFV TSENQLVYYP SITYAIIGSS 190 200 210 220 230 240 VIFVLVVALL ALVLHHQRKR NNLMTLPVHR LQHPVLLSRL VVLDHPHHCN VTYNVNNGIQ 250 260 270 280 290 300 YVASQAEQNA SEVGSPPSYS EALLDQRPAW YDLPPPPYSS DTESLNQADL PPYRSRSGSA 310 320 330 340 NSASSQAASS LLSVEDTSHS PGQPGPQEGT AEPRDSEPSQ GTEEV

CATM prediction

The sequence of LRAD3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           180       190     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 SITYAIIGSSVIFVLVVALLALVLHHQ 7.3 -42.8° 4.5 34.8 -9.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 175, ALA, HA A, 174, TYR, O 3.29Å
B, 178, GLY, HA1 A, 175, ALA, O 3.47Å
A, 175, ALA, HA B, 174, TYR, O 3.29Å
A, 178, GLY, HA1 B, 175, ALA, O 3.47Å