UniProt data
UniProt name: TMM25_HUMAN (Q86YD3)
Gene name: TMEM25; ORFNames=UNQ2531/PRO6030
Organism: Homo sapiens (Human).
Function:
Subcellular location: Isoform 3: Secreted {ECO:0000305}.
Transmembrane domains:
- 233-253, 21 AA, Helical. {ECO:0000255}.
Sequence: 366 AA
10 20 30 40 50 60
MALPPGPAAL RHTLLLLPAL LSSGWGELEP QIDGQTWAER ALRENERHAF TCRVAGGPGT
70 80 90 100 110 120
PRLAWYLDGQ LQEASTSRLL SVGGEAFSGG TSTFTVTAHR AQHELNCSLQ DPRSGRSANA
130 140 150 160 170 180
SVILNVQFKP EIAQVGAKYQ EAQGPGLLVV LFALVRANPP ANVTWIDQDG PVTVNTSDFL
190 200 210 220 230 240
VLDAQNYPWL TNHTVQLQLR SLAHNLSVVA TNDVGVTSAS LPAPGLLATR VEVPLLGIVV
250 260 270 280 290 300
AAGLALGTLV GFSTLVACLV CRKEKKTKGP SRHPSLISSD SNNLKLNNVR LPRENMSLPS
310 320 330 340 350 360
NLQLNDLTPD SRAVKPADRQ MAQNNSRPEL LDPEPGGLLT SQGFIRLPVL GYIYRVSSVS
SDEIWL
CATM prediction
The sequence of TMM25_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 230 240 250 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RVEVALLGIVVAAGLALGTLVGFSTLV | 7.2 | -41.9° | 1.4 | 44.8 | -19.5 |
| Model 2 | RVEVALLGIVVAAGLALGTLVGFSTLV | 6.4 | -44.8° | 4.4 | 54.9 | -18.9 |
| Model 3 | RVEVALLGIVVAAGLALGTLVGFSTLV | 7.3 | -53.2° | 3.2 | 33.9 | -8.2 |
| Prolines* | RVEVPLLGIVVAAGLALGTLVGFSTLV |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 234, ALA, HA | A, 233, VAL, O | 3.34Å |
| B, 237, GLY, HA1 | A, 234, ALA, O | 3.11Å |
| B, 238, ILE, HA | A, 237, GLY, O | 3.29Å |
| A, 234, ALA, HA | B, 233, VAL, O | 3.34Å |
| A, 237, GLY, HA1 | B, 234, ALA, O | 3.11Å |
| A, 238, ILE, HA | B, 237, GLY, O | 3.29Å |
