UniProt data
UniProt name: ZGRF1_HUMAN (Q86YA3)
Gene name: ZGRF1; Synonyms=C4orf21
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 1944-1964, 21 AA, Helical. {ECO:0000255}.
Sequence: 2104 AA
10 20 30 40 50 60
MESQEFIVLY THQKMKKSKV WQDGILKITH LGNKAILYDD KGACLESLFL KCLEVKPGDD
70 80 90 100 110 120
LESDRYLITV EEVKVAGAIG IVKQNVNKEA PELNSRTFIS SGRSLGCQPS GLKRKFTGFQ
130 140 150 160 170 180
GPRQVPKKMV IMESGESAAS HEAKKTGPTI FSPFCSMPPL FPTVGKKDVN NILADPENIV
190 200 210 220 230 240
TYKNRERNAM DFSSVFSPSF QINPEVLCEE NYFCSPVNSG NKLSDSLLTN EPVKRDSLAS
250 260 270 280 290 300
HYSGVSQNIR SKAQILALLK SESSSSCEEL NSEMTEHFPQ KQPQGSLKIA TKPKYLIQQE
310 320 330 340 350 360
ECAEMKSTEN LYYQHQSENT MRNKSRWAMY LSSQSSPIHS STVDGNDTER KPKAQEDDVN
370 380 390 400 410 420
SNLKDLSLQK IIQFVETYAE ERKKYNVDQS VGNNDPSWNQ EVKLEIPSFN ESSSLQVTCS
430 440 450 460 470 480
SAENDGILSE SDIQEDNKIP FNQNDKGCIK GSVLIKENAQ EVNTCGTLEK EYEQSESSLP
490 500 510 520 530 540
ELKHLQIESS NNSRISDDIT DMISESKMDN ESLNSIHESL SNVTQPFLEV TFNLNNFETS
550 560 570 580 590 600
DTEEESQESN KISQDSESWV KDILVNDGNS CFQKRSENTN CEEIEGEHLP FLTSVSDKPT
610 620 630 640 650 660
VTFPVKETLP SQFCDKTYVG FDMGICKTEN TGKEIEEYSD TLSNFESFKW TDAVYGDNKE
670 680 690 700 710 720
DANKPIQEVR INYDFALPPN KSKGINMNLH IPHIQNQIAE NSNLFSEDAQ PQPFILGSDL
730 740 750 760 770 780
DKNDEHVLPS TSSSDNSVQL LNTNQNHYEC IALDKSNTHI SNSLFYPLGK KHLISKDTEA
790 800 810 820 830 840
HISEPEDLGK IRSPPPDHVE VETAREGKQY WNPRNSSELS GLVNTISILK SLCEHSTALD
850 860 870 880 890 900
SLEILKKKNT VFQQGTQQTY EPDSPPEVRK PFITVVSPKS PHLHKDSQQI LKEDEVELSE
910 920 930 940 950 960
PLQSVQFSSS GSKEETAFQA VIPKQIERKT CDPKPVEFQG HQVKGSATSG VMVRGHSSQL
970 980 990 1000 1010 1020
GCSQFPDSTE YENFMTETPE LPSTCMQIDF LQVTSPEENI STLSPVSTFS LNSRDEDFMV
1030 1040 1050 1060 1070 1080
EFSETSLKAR TLPDDLHFLN LEGMKKSRSL ENENLQRLSL LSRTQVPLIT LPRTDGPPDL
1090 1100 1110 1120 1130 1140
DSHSYMINSN TYESSGSPML NLCEKSAVLS FSIEPEDQNE TFFSEESREV NPGDVSLNNI
1150 1160 1170 1180 1190 1200
STQSKWLKYQ NTSQCNVATP NRVDKRITDG FFAEAVSGMH FRDTSERQSD AVNESSLDSV
1210 1220 1230 1240 1250 1260
HLQMIKGMLY QQRQDFSSQD SVSRKKVLSL NLKQTSKTEE IKNVLGGSTC YNYSVKDLQE
1270 1280 1290 1300 1310 1320
ISGSELCFPS GQKIKSAYLP QRQIHIPAVF QSPAHYKQTF TSCLIEHLNI LLFGLAQNLQ
1330 1340 1350 1360 1370 1380
KALSKVDISF YTSLKGEKLK NAENNVPSCH HSQPAKLVMV KKEGPNKGRL FYTCDGPKAD
1390 1400 1410 1420 1430 1440
RCKFFKWLED VTPGYSTQEG ARPGMVLSDI KSIGLYLRSQ KIPLYEECQL LVRKGFDFQR
1450 1460 1470 1480 1490 1500
KQYGKLKKFT TVNPEFYNEP KTKLYLKLSR KERSSAYSKN DLWVVSKTLD FELDTFIACS
1510 1520 1530 1540 1550 1560
AFFGPSSINE IEILPLKGYF PSNWPTNMVV HALLVCNAST ELTTLKNIQD YFNPATLPLT
1570 1580 1590 1600 1610 1620
QYLLTTSSPT IVSNKRVSKR KFIPPAFTNV STKFELLSLG ATLKLASELI QVHKLNKDQA
1630 1640 1650 1660 1670 1680
TALIQIAQMM ASHESIEEVK ELQTHTFPIT IIHGVFGAGK SYLLAVVILF FVQLFEKSEA
1690 1700 1710 1720 1730 1740
PTIGNARPWK LLISSSTNVA VDRVLLGLLS LGFENFIRVG SVRKIAKPIL PYSLHAGSEN
1750 1760 1770 1780 1790 1800
ESEQLKELHA LMKEDLTPTE RVYVRKSIEQ HKLGTNRTLL KQVRVVGVTC AACPFPCMND
1810 1820 1830 1840 1850 1860
LKFPVVVLDE CSQITEPASL LPIARFECEK LILVGDPKQL PPTIQGSDAA HENGLEQTLF
1870 1880 1890 1900 1910 1920
DRLCLMGHKP ILLRTQYRCH PAISAIANDL FYKGALMNGV TEIERSPLLE WLPTLCFYNV
1930 1940 1950 1960 1970 1980
KGLEQIERDN SFHNVAEATF TLKLIQSLIA SGIAGSMIGV ITLYKSQMYK LCHLLSAVDF
1990 2000 2010 2020 2030 2040
HHPDIKTVQV STVDAFQGAE KEIIILSCVR TRQVGFIDSE KRMNVALTRG KRHLLIVGNL
2050 2060 2070 2080 2090 2100
ACLRKNQLWG RVIQHCEGRE DGLQHANQYE PQLNHLLKDY FEKQVEEKQK KKSEKEKSKD
KSHS
CATM prediction
The sequence of ZGRF1_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 1950 1960 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | TLKLIQSLIASGIAGSMIGVITLYKSQ | 7.2 | -53.0° | 1.9 | 45.2 | -21.5 |
| Model 2 | TLKLIQSLIASGIAGSMIGVITLYKSQ | 6.8 | -52.2° | 1.8 | 35.1 | -18.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 1952, GLY, HA1 | A, 1949, ILE, O | 3.30Å |
| B, 1953, ILE, HA | A, 1952, GLY, O | 3.48Å |
| B, 1956, SER, HG1 | A, 1953, ILE, O | 2.62Å |
| A, 1952, GLY, HA1 | B, 1949, ILE, O | 3.30Å |
| A, 1953, ILE, HA | B, 1952, GLY, O | 3.48Å |
| A, 1956, SER, HG1 | B, 1953, ILE, O | 2.62Å |
| A, 1964, TYR, HH | B, 1964, TYR, OH | 1.85Å |
