Insulin-like growth factor-binding protein 3 receptor

UniProt data

UniProt name: TM219_HUMAN (Q86XT9)

Gene name: TMEM219

Organism: Homo sapiens (Human).

Function: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. {ECO:0000269|PubMed:20353938}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:20353938}; Single-pass membrane protein {ECO:0000269|PubMed:20353938}.

Transmembrane domains:

  1. 205-225, 21 AA, Helical. {ECO:0000255}.

Sequence: 240 AA

10 20 30 40 50 60 MGNCQAGHNL HLCLAHHPPL VCATLILLLL GLSGLGLGSF LLTHRTGLRS PDIPQDWVSF 70 80 90 100 110 120 LRSFGQLTLC PRNGTVTGKW RGSHVVGLLT TLNFGDGPDR NKTRTFQATV LGSQMGLKGS 130 140 150 160 170 180 SAGQLVLITA RVTTERTAGT CLYFSAVPGI LPSSQPPISC SEEGAGNATL SPRMGEECVS 190 200 210 220 230 VWSHEGLVLT KLLTSEELAL CGSRLLVLGS FLLLFCGLLC CVTAMCFHPR RESHWSRTRL

CATM prediction

The sequence of TM219_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          210       220      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GSRLLVLGSFLLLFCGLLCCVTAMCFH 7.3 -51.0° 2.4 45.0 -8.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 214, LEU, HA A, 213, LEU, O 3.49Å
B, 217, GLY, HA1 A, 214, LEU, O 3.27Å
A, 214, LEU, HA B, 213, LEU, O 3.49Å
A, 217, GLY, HA1 B, 214, LEU, O 3.27Å