Cation channel sperm-associated protein subunit delta

UniProt data

UniProt name: CTSRD_HUMAN (Q86XM0)

Gene name: CATSPERD; Synonyms=TMEM146

Organism: Homo sapiens (Human).

Function: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane (By similarity). {ECO:0000250}.

Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Specifically located in the principal piece of sperm tail. {ECO:0000250}.

Transmembrane domains:

  1. 719-739, 21 AA, Helical. {ECO:0000255}.

Sequence: 798 AA

10 20 30 40 50 60 MLMLMLVAAV TMWLRPLVTA QLCRSRTVRT GKVFNLIQDV QGDRLYFHPT TTRLIKHPCE 70 80 90 100 110 120 KNIALYLGKQ VFFTMDNFET SLLPFTIPTS MQVGVPEVTS AHFAGSLLLL VVDQKVYIYD 130 140 150 160 170 180 YENNSWSMSL GIKHPVTHVS GDNCCYTGSL FCVHVSNLVF AYFRGDQISQ TYIYYSNTGG 190 200 210 220 230 240 FSFWKYHYDR QAEIIGSLGG IFHFFSLSQV AMLVVNQGKG MFKYSDHPLN RSFGLSFDYN 250 260 270 280 290 300 GTLDILIAPG QRGILLLWFE NSLLFSHNAG QLVDTVRVKK GDQTLFSSIF EAKITIHNIA 310 320 330 340 350 360 VTENELAVIT REDNLYYGNL GIVPSSIIKF ADQYIWSEDV ALMFRSPGTL EILTPLRDTA 370 380 390 400 410 420 FPAFDFQKCL VNIQALLMDP ELHVGKCKIE FLTGEFIYRM YTIDMHSQLE LTASLIPQPG 430 440 450 460 470 480 TSLIPLVMVS NPHSLGFQAT FYENGYTSDG NTKYKLDIFL KQQQHWGRTD SNFTSSLKKA 490 500 510 520 530 540 TMSTLTVDIA NKEISCVDIK PLSTLISVGC DLDKKIVIQN KVSACSMGIL DPLTLQDNYS 550 560 570 580 590 600 FIIEKEFYDP GFQGQQSSED LHVFYSYQQL GCPLLVYYDT LWKPVVELWR KDSFQEVIDA 610 620 630 640 650 660 EYVLLEVNGQ FSYSYSLTAQ SAMCTSQPQN WTTMIKEFGG PFFWNRENYV SCHDPNNNAP 670 680 690 700 710 720 LRWPDVQYQI LGGRTANQII FGHNGFYVFY ISIVDPYYSY CQLETIFSIY VYGAFPVQLV 730 740 750 760 770 780 SAGVVILLII SSILGSVWLA YKTPKLLRTA RGRRIKKCAT QLCRRCKTVC QFRASATARA 790 GTEPPGRHRT PHGGRSDH

CATM prediction

The sequence of CTSRD_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      720       730       740
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 AVQLVSAGVVILLIISSILGSVWLAYK 7.0 -48.2° 3.3 33.6 -7.8
Prolines* PVQLVSAGVVILLIISSILGSVWLAYK          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 728, LEU, HA A, 731, SER, OG 3.36Å
B, 732, SER, HA A, 731, SER, O 3.31Å
B, 735, GLY, HA1 A, 732, SER, O 3.23Å
A, 728, LEU, HA B, 731, SER, OG 3.36Å
A, 732, SER, HA B, 731, SER, O 3.31Å
A, 735, GLY, HA1 B, 732, SER, O 3.23Å