V-set and immunoglobulin domain-containing protein 1

UniProt data

UniProt name: VSIG1_HUMAN (Q86XK7)

Gene name: VSIG1; Synonyms=GPA34

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 233-253, 21 AA, Helical. {ECO:0000255}.

Sequence: 387 AA

10 20 30 40 50 60 MVFAFWKVFL ILSCLAGQVS VVQVTIPDGF VNVTVGSNVT LICIYTTTVA SREQLSIQWS 70 80 90 100 110 120 FFHKKEMEPI SIYFSQGGQA VAIGQFKDRI TGSNDPGNAS ITISHMQPAD SGIYICDVNN 130 140 150 160 170 180 PPDFLGQNQG ILNVSVLVKP SKPLCSVQGR PETGHTISLS CLSALGTPSP VYYWHKLEGR 190 200 210 220 230 240 DIVPVKENFN PTTGILVIGN LTNFEQGYYQ CTAINRLGNS SCEIDLTSSH PEVGIIVGAL 250 260 270 280 290 300 IGSLVGAAII ISVVCFARNK AKAKAKERNS KTIAELEPMT KINPRGESEA MPREDATQLE 310 320 330 340 350 360 VTLPSSIHET GPDTIQEPDY EPKPTQEPAP EPAPGSEPMA VPDLDIELEL EPETQSELEP 370 380 EPEPEPESEP GVVVEPLSED EKGVVKA

CATM prediction

The sequence of VSIG1_HUMAN returned 12 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  230       240       250    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 HAEVGIIVGALIGSLVGAAIIISVVCF 6.5 -34.9° 6.0 48.9 -43.6
Model 2 HAEVGIIVGALIGSLVGAAIIISVVCF 6.5 -36.1° 2.2 48.0 -34.1
Model 3 HAEVGIIVGALIGSLVGAAIIISVVCF 7.2 -23.0° 5.1 55.0 -29.5
Model 4 HAEVGIIVGALIGSLVGAAIIISVVCF 6.4 -42.8° 2.3 62.0 -29.4
Model 5 HAEVGIIVGALIGSLVGAAIIISVVCF 6.5 -47.1° 1.3 45.1 -28.6
Model 6 HAEVGIIVGALIGSLVGAAIIISVVCF 6.5 -55.0° 5.5 40.1 -20.1
Model 7 HAEVGIIVGALIGSLVGAAIIISVVCF 6.8 -30.0° 3.5 53.0 -18.0
Model 8 HAEVGIIVGALIGSLVGAAIIISVVCF 6.6 -55.0° 5.0 52.9 -17.2
Model 9 HAEVGIIVGALIGSLVGAAIIISVVCF 7.3 -45.9° 3.6 36.9 -15.9
Model 10 HAEVGIIVGALIGSLVGAAIIISVVCF 7.0 -51.9° 1.8 35.0 -10.3
Model 11 HAEVGIIVGALIGSLVGAAIIISVVCF 6.9 -40.0° 5.1 44.0 -8.0
Model 12 HAEVGIIVGALIGSLVGAAIIISVVCF 7.4 -54.0° 3.6 35.0 -0.2
Prolines* HPEVGIIVGALIGSLVGAAIIISVVCF          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 235, ILE, HA A, 234, GLY, O 2.98Å
B, 238, GLY, HA1 A, 235, ILE, O 2.71Å
B, 239, ALA, HA A, 238, GLY, O 2.34Å
B, 242, GLY, HA1 A, 239, ALA, O 3.07Å
A, 235, ILE, HA B, 234, GLY, O 2.98Å
A, 238, GLY, HA1 B, 235, ILE, O 2.71Å
A, 239, ALA, HA B, 238, GLY, O 2.34Å
A, 242, GLY, HA1 B, 239, ALA, O 3.07Å