UniProt data
UniProt name: MICU3_HUMAN (Q86XE3)
Gene name: MICU3; Synonyms=EFHA2
Organism: Homo sapiens (Human).
Function: May play a role in mitochondrial calcium uptake. {ECO:0000250}.
Subcellular location: Mitochondrion {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 67-83, 17 AA, Helical. {ECO:0000255}.
Sequence: 530 AA
10 20 30 40 50 60
MAALRRLLWP PPRVSPPLCA HQPLLGPWGR PAVTTLGLPG RPFSSREDEE RAVAEAAWRR
70 80 90 100 110 120
RRRWGELSVA AAAGGGLVGL VCYQLYGDPR AGSPATGRPS KSAATEPEDP PRGRGMLPIP
130 140 150 160 170 180
VAAAKETVAI GRTDIEDLDL YATSRERRFR LFASIECEGQ LFMTPYDFIL AVTTDEPKVA
190 200 210 220 230 240
KTWKSLSKQE LNQMLAETPP VWKGSSKLFR NLKEKGVISY TEYLFLLCIL TKPHAGFRIA
250 260 270 280 290 300
FNMFDTDGNE MVDKKEFLVL QEIFRKKNEK REIKGDEEKR AMLRLQLYGY HSPTNSVLKT
310 320 330 340 350 360
DAEELVSRSY WDTLRRNTSQ ALFSDLAERA DDITSLVTDT TLLVHFFGKK GKAELNFEDF
370 380 390 400 410 420
YRFMDNLQTE VLEIEFLSYS NGMNTISEED FAHILLRYTN VENTSVFLEN VRYSIPEEKG
430 440 450 460 470 480
ITFDEFRSFF QFLNNLEDFA IALNMYNFAS RSIGQDEFKR AVYVATGLKF SPHLVNTVFK
490 500 510 520
IFDVDKDDQL SYKEFIGIMK DRLHRGFRGY KTVQKYPTFK SCLKKELHSR
CATM prediction
The sequence of MICU3_HUMAN returned 5 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 70 80 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | WGELSVAAAAGGGLVGLVCYQLY | 6.9 | -31.9° | 2.9 | 50.0 | -37.4 |
| Model 2 | WGELSVAAAAGGGLVGLVCYQLY | 6.7 | -45.7° | 3.6 | 37.0 | -32.0 |
| Model 3 | WGELSVAAAAGGGLVGLVCYQLY | 6.7 | -47.8° | -0.0 | 38.0 | -16.9 |
| Model 4 | WGELSVAAAAGGGLVGLVCYQLY | 6.9 | -51.8° | 1.3 | 56.9 | -16.6 |
| Model 5 | WGELSVAAAAGGGLVGLVCYQLY | 7.0 | -51.2° | 3.3 | 48.2 | -13.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 68, SER, HA | A, 68, SER, OG | 3.48Å |
| B, 72, ALA, HA | A, 71, ALA, O | 2.78Å |
| B, 75, GLY, HA1 | A, 72, ALA, O | 3.06Å |
| B, 76, GLY, HA2 | A, 75, GLY, O | 3.28Å |
| A, 68, SER, HA | B, 68, SER, OG | 3.48Å |
| A, 72, ALA, HA | B, 71, ALA, O | 2.78Å |
| A, 75, GLY, HA1 | B, 72, ALA, O | 3.06Å |
| A, 76, GLY, HA2 | B, 75, GLY, O | 3.28Å |
