Amphoterin-induced protein 3

UniProt data

UniProt name: AMGO3_HUMAN (Q86WK7)

Gene name: AMIGO3 {ECO:0000312|EMBL:AAO48944.1}

Organism: Homo sapiens (Human).

Function: May mediate heterophilic cell-cell interaction. May contribute to signal transduction through its intracellular domain (By similarity). {ECO:0000250|UniProtKB:Q80ZD5}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 384-404, 21 AA, Helical. {ECO:0000255}.

Sequence: 504 AA

10 20 30 40 50 60 MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP 70 80 90 100 110 120 AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT 130 140 150 160 170 180 LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL 190 200 210 220 230 240 SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS 250 260 270 280 290 300 AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC 310 320 330 340 350 360 NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH 370 380 390 400 410 420 HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP 430 440 450 460 470 480 QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN 490 500 PGGLQLKAGS ESASSIGSEG PMTT

CATM prediction

The sequence of AMGO3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           390       400     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 FNTGFTTLLGCAVGLVLVLLYLFAAAC 6.7 -48.0° 0.8 54.0 -26.9
Prolines* FNTGFTTLLGCAVGLVLVLLYLFAPPC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 387, THR, HA A, 386, THR, O 3.30Å
B, 390, GLY, HA1 A, 387, THR, O 2.87Å
B, 391, CYS, HA A, 390, GLY, O 2.89Å
A, 387, THR, HA B, 386, THR, O 3.30Å
A, 390, GLY, HA1 B, 387, THR, O 2.87Å
A, 391, CYS, HA B, 390, GLY, O 2.89Å