Amphoterin-induced protein 1

UniProt data

UniProt name: AMGO1_HUMAN (Q86WK6)

Gene name: AMIGO1 {ECO:0000312|HGNC:HGNC:20824}

Organism: Homo sapiens (Human).

Function: Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:Q80ZD8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q80ZD8}. Perikaryon {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q80ZD8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80ZD7}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal and cortical neurons. Associated with axons of neuronal cells. {ECO:0000250|UniProtKB:Q80ZD7, ECO:0000250|UniProtKB:Q80ZD8}.

Transmembrane domains:

  1. 373-393, 21 AA, Helical. {ECO:0000255}.

Sequence: 493 AA

10 20 30 40 50 60 MHPHRDPRGL WLLLPSLSLL LFEVARAGRA VVSCPAACLC ASNILSCSKQ QLPNVPHSLP 70 80 90 100 110 120 SYTALLDLSH NNLSRLRAEW TPTRLTQLHS LLLSHNHLNF ISSEAFSPVP NLRYLDLSSN 130 140 150 160 170 180 QLRTLDEFLF SDLQVLEVLL LYNNHIMAVD RCAFDDMAQL QKLYLSQNQI SRFPLELVKE 190 200 210 220 230 240 GAKLPKLTLL DLSSNKLKNL PLPDLQKLPA WIKNGLYLHN NPLNCDCELY QLFSHWQYRQ 250 260 270 280 290 300 LSSVMDFQED LYCMNSKKLH NVFNLSFLNC GEYKERAWEA HLGDTLIIKC DTKQQGMTKV 310 320 330 340 350 360 WVTPSNERVL DEVTNGTVSV SKDGSLLFQQ VQVEDGGVYT CYAMGETFNE TLSVELKVHN 370 380 390 400 410 420 FTLHGHHDTL NTAYTTLVGC ILSVVLVLIY LYLTPCRCWC RGVEKPSSHQ GDSLSSSMLS 430 440 450 460 470 480 TTPNHDPMAG GDKDDGFDRR VAFLEPAGPG QGQNGKLKPG NTLPVPEATG KGQRRMSDPE 490 SVSSVFSDTP IVV

CATM prediction

The sequence of AMGO1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  370       380       390    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 LNTAYTTLVGCILSVVLVLIYLYLTAC 7.0 -53.0° 2.0 44.8 -16.6
Prolines* LNTAYTTLVGCILSVVLVLIYLYLTPC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 376, THR, HA A, 375, THR, O 3.42Å
B, 379, GLY, HA1 A, 376, THR, O 2.86Å
B, 380, CYS, HA A, 379, GLY, O 3.15Å
B, 383, SER, HG1 A, 380, CYS, O 2.56Å
A, 376, THR, HA B, 375, THR, O 3.42Å
A, 379, GLY, HA1 B, 376, THR, O 2.86Å
A, 380, CYS, HA B, 379, GLY, O 3.15Å
A, 383, SER, HG1 B, 380, CYS, O 2.56Å