Catechol O-methyltransferase domain-containing protein 1

UniProt data

UniProt name: CMTD1_HUMAN (Q86VU5)

Gene name: COMTD1; ORFNames=UNQ766/PRO1558

Organism: Homo sapiens (Human).

Function: Putative O-methyltransferase. {ECO:0000305}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 12-32, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 262 AA

10 20 30 40 50 60 MTQPVPRLSV PAALALGSAA LGAAFATGLF LGRRCPPWRG RREQCLLPPE DSRLWQYLLS 70 80 90 100 110 120 RSMREHPALR SLRLLTLEQP QGDSMMTCEQ AQLLANLARL IQAKKALDLG TFTGYSALAL 130 140 150 160 170 180 ALALPADGRV VTCEVDAQPP ELGRPLWRQA EAEHKIDLRL KPALETLDEL LAAGEAGTFD 190 200 210 220 230 240 VAVVDADKEN CSAYYERCLQ LLRPGGILAV LRVLWRGKVL QPPKGDVAAE CVRNLNERIR 250 260 RDVRVYISLL PLGDGLTLAF KI

CATM prediction

The sequence of CMTD1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   10        20        30    
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 SVAAALALGSAALGAAFATGLFLGRRC 6.6 -34.1° 0.1 57.0 -39.7
Model 2 SVAAALALGSAALGAAFATGLFLGRRC 6.9 -43.0° 2.4 44.0 -24.2
Model 3 SVAAALALGSAALGAAFATGLFLGRRC 7.2 -47.9° -0.0 38.3 -19.7
Model 4 SVAAALALGSAALGAAFATGLFLGRRC 7.2 -53.7° 2.9 51.0 -9.7
Prolines* SVPAALALGSAALGAAFATGLFLGRRC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 25, PHE, HA A, 24, ALA, O 2.91Å
B, 28, GLY, HA1 A, 25, PHE, O 2.88Å
B, 29, LEU, HA A, 28, GLY, O 2.66Å
A, 25, PHE, HA B, 24, ALA, O 2.91Å
A, 28, GLY, HA1 B, 25, PHE, O 2.88Å
A, 29, LEU, HA B, 28, GLY, O 2.66Å