Leucine-rich repeat transmembrane neuronal protein 3

UniProt data

UniProt name: LRRT3_HUMAN (Q86VH5)

Gene name: LRRTM3; ORFNames=UNQ803/PRO1693

Organism: Homo sapiens (Human).

Function: Exhibits a limited synaptogenic activity in vitro, restricted to excitatory presynaptic differentiation (By similarity). May play a role in the development and maintenance of the vertebrate nervous system. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 420-440, 21 AA, Helical. {ECO:0000255}.

Sequence: 581 AA

10 20 30 40 50 60 MGFNVIRLLS GSAVALVIAP TVLLTMLSSA ERGCPKGCRC EGKMVYCESQ KLQEIPSSIS 70 80 90 100 110 120 AGCLGLSLRY NSLQKLKYNQ FKGLNQLTWL YLDHNHISNI DENAFNGIRR LKELILSSNR 130 140 150 160 170 180 ISYFLNNTFR PVTNLRNLDL SYNQLHSLGS EQFRGLRKLL SLHLRSNSLR TIPVRIFQDC 190 200 210 220 230 240 RNLELLDLGY NRIRSLARNV FAGMIRLKEL HLEHNQFSKL NLALFPRLVS LQNLYLQWNK 250 260 270 280 290 300 ISVIGQTMSW TWSSLQRLDL SGNEIEAFSG PSVFQCVPNL QRLNLDSNKL TFIGQEILDS 310 320 330 340 350 360 WISLNDISLA GNIWECSRNI CSLVNWLKSF KGLRENTIIC ASPKELQGVN VIDAVKNYSI 370 380 390 400 410 420 CGKSTTERFD LARALPKPTF KPKLPRPKHE SKPPLPPTVG ATEPGPETDA DAEHISFHKI 430 440 450 460 470 480 IAGSVALFLS VLVILLVIYV SWKRYPASMK QLQQRSLMRR HRKKKRQSLK QMTPSTQEFY 490 500 510 520 530 540 VDYKPTNTET SEMLLNGTGP CTYNKSGSRE CEIPLSMNVS TFLAYDQPTI SYCGVHHELL 550 560 570 580 SHKSFETNAQ EDTMETHLET ELDLSTITTA GRISDHKQQL A

CATM prediction

The sequence of LRRT3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     420       430       440 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 FHKIIAGSVALFLSVLVILLVIYVSWK 7.2 -37.0° 2.2 36.0 -5.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 423, GLY, HA2 A, 422, ALA, O 3.38Å
A, 423, GLY, HA2 B, 422, ALA, O 3.38Å