Leucine-rich repeat transmembrane neuronal protein 4

UniProt data

UniProt name: LRRT4_HUMAN (Q86VH4)

Gene name: LRRTM4; ORFNames=UNQ3075/PRO9907

Organism: Homo sapiens (Human).

Function: May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 425-445, 21 AA, Helical. {ECO:0000255}.

Sequence: 590 AA

10 20 30 40 50 60 MGFHLITQLK GMSVVLVLLP TLLLVMLTGA QRACPKNCRC DGKIVYCESH AFADIPENIS 70 80 90 100 110 120 GGSQGLSLRF NSIQKLKSNQ FAGLNQLIWL YLDHNYISSV DEDAFQGIRR LKELILSSNK 130 140 150 160 170 180 ITYLHNKTFH PVPNLRNLDL SYNKLQTLQS EQFKGLRKLI ILHLRSNSLK TVPIRVFQDC 190 200 210 220 230 240 RNLDFLDLGY NRLRSLSRNA FAGLLKLKEL HLEHNQFSKI NFAHFPRLFN LRSIYLQWNR 250 260 270 280 290 300 IRSISQGLTW TWSSLHNLDL SGNDIQGIEP GTFKCLPNLQ KLNLDSNKLT NISQETVNAW 310 320 330 340 350 360 ISLISITLSG NMWECSRSIC PLFYWLKNFK GNKESTMICA GPKHIQGEKV SDAVETYNIC 370 380 390 400 410 420 SEVQVVNTER SHLVPQTPQK PLIIPRPTIF KPDVTQSTFE TPSPSPGFQI PGAEQEYEHV 430 440 450 460 470 480 SFHKIIAGSV ALFLSVAMIL LVIYVSWKRY PASMKQLQQH SLMKRRRKKA RESERQMNSP 490 500 510 520 530 540 LQEYYVDYKP TNSETMDISV NGSGPCTYTI SGSRECEMPH HMKPLPYYSY DQPVIGYCQA 550 560 570 580 HQPLHVTKGY ETVSPEQDES PGLELGRDHS FIATIARSAA PAIYLERIAN

CATM prediction

The sequence of LRRT4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          430       440      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 FHKIIAGSVALFLSVAMILLVIYVSWK 7.2 -37.0° 2.2 36.0 -6.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 428, GLY, HA2 A, 427, ALA, O 3.38Å
A, 428, GLY, HA2 B, 427, ALA, O 3.38Å