Uncharacterized protein C14orf37

UniProt data

UniProt name: CN037_HUMAN (Q86TY3)

Gene name: C14orf37

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 715-735, 21 AA, Helical. {ECO:0000255}.

Sequence: 774 AA

10 20 30 40 50 60 MRGPIVLHIC LAFCSLLLFS VATQCLAFPK IERRREIAHV HAEKGQSDKM NTDDLENSSV 70 80 90 100 110 120 TSKQTPQLVV SEDPMMMSAV PSATSLNKAF SINKETQPGQ AGLMQTERPG VSTPTESGVP 130 140 150 160 170 180 SAEEVFGSSQ PERISPESGL AKAMLTIAIT ATPSLTVDEK EELLTSTNFQ PIVEEITETT 190 200 210 220 230 240 KGFLKYMDNQ SFATESQEGV GLGHSPSSYV NTKEMLTTNP KTEKFEADTD HRTTSFPGAE 250 260 270 280 290 300 STAGSEPGSL TPDKEKPSQM TADNTQAAAT KQPLETSEYT LSVEPETDSL LGAPEVTVSV 310 320 330 340 350 360 STAVPAASAL SDEWDDTKLE SVSRIRTPKL GDNEETQVRT EMSQTAQVSH EGMEGGQPWT 370 380 390 400 410 420 EAAQVALGLP EGETHTGTAL LIAHGNERSP AFTDQSSFTP TSLMEDMKVS IVNLLQSTGD 430 440 450 460 470 480 FTESTKENDA LFFLETTVSV SVYESEADQL LGNTMKDIIT QEMTTAVQEP DATLSMVTQE 490 500 510 520 530 540 QVATLELIRD SGKTEEEKED PSPVSDVPGV TQLSRRWEPL ATTISTTVVP LSFEVTPTVE 550 560 570 580 590 600 EQMDTVTGPN EEFTPVLGSP VTPPGIMVGE PSISPALPAL EASSERRTVV PSITRVNTAA 610 620 630 640 650 660 SYGLDQLESE EGQEDEDEED EEDEDEEEED EEEDEEDKDA DSLDEGLDGD TELPGFTLPG 670 680 690 700 710 720 ITSQEPGLEE GNMDLLEGAT YQVPDALEWE QQNQGLVRSW MEKLKDKAGY MSGMLVPVGV 730 740 750 760 770 GIAGALFILG ALYSIKVMNR RRRNGFKRHK RKQREFNSMQ DRVMLLADSS EDEF

CATM prediction

The sequence of CN037_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          720       730      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 SGMLVAVGVGIAGALFILGALYSIKVM 6.9 -50.0° 2.9 46.8 -36.4
Model 2 SGMLVAVGVGIAGALFILGALYSIKVM 7.4 -45.9° 3.6 37.0 -16.7
Model 3 SGMLVAVGVGIAGALFILGALYSIKVM 7.2 -53.0° 1.9 45.2 -15.4
Model 4 SGMLVAVGVGIAGALFILGALYSIKVM 6.8 -55.0° 0.9 50.0 -15.4
Prolines* SGMLVPVGVGIAGALFILGALYSIKVM          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 718, VAL, HA A, 717, ALA, O 3.10Å
B, 721, GLY, HA1 A, 718, VAL, O 2.96Å
A, 718, VAL, HA B, 717, ALA, O 3.10Å
A, 721, GLY, HA1 B, 718, VAL, O 2.96Å
A, 733, TYR, HH B, 733, TYR, OH 2.43Å