E3 ubiquitin-protein ligase RNF180

UniProt data

UniProt name: RN180_HUMAN (Q86T96)

Gene name: RNF180

Organism: Homo sapiens (Human).

Function: E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope {ECO:0000250}.

Transmembrane domains:

  1. 565-585, 21 AA, Helical. {ECO:0000255}.

Sequence: 592 AA

10 20 30 40 50 60 MKRSKELITK NHSQEETSIL RCWKCRKCIA SSGCFMEYLE NQVIKDKDDS VDAQNICHVW 70 80 90 100 110 120 HMNVEALPEW ISCLIQKAQW TVGKLNCPFC GARLGGFNFV STPKCSCGQL AAVHLSKSRT 130 140 150 160 170 180 DYQPTQAGRL MRPSVKYLSH PRVQSGCDKE ALLTGGGSEN RNHRLLNMAR NNNDPGRLTE 190 200 210 220 230 240 ALCLEVRPTY FEMKNEKLLS KASEPKYQLF VPQLVTGRCA TRAFHRKSHS LDLNISEKLT 250 260 270 280 290 300 LLPTLYEIHS KTTAYSRLNE TQPIDLSGLP LQSSKNSYSF QNPSSFDPSM LLQRFSVAPH 310 320 330 340 350 360 ETQTQRGGEF QCGLEAASVY SDHTNTNNLT FLMDLPSAGR SMPEASDQEE HLSPLDFLHS 370 380 390 400 410 420 ANFSLGSINQ RLNKRERSKL KNLRRKQRRR ERWLQKQGKY SGVGLLDHMT LNNEMSTDED 430 440 450 460 470 480 NEYAEEKDSY ICAVCLDVYF NPYMCYPCHH IFCEPCLRTL AKDNPSSTPC PLCRTIISRV 490 500 510 520 530 540 FFQTELNNAT KTFFTKEYLK IKQSFQKSNS AKWPLPSCRK AFHLFGGFRR HAAPVTRRQF 550 560 570 580 590 PHGAHRMDYL HFEDDSRGWW FDMDMVIIYI YSVNWVIGFI VFCFLCYFFF PF

CATM prediction

The sequence of RN180_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          570       580      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 DMDMVIIYIYSVNWVIGFIVFCFLCYF 7.4 -54.0° 3.6 48.9 -5.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 571, TYR, HA A, 574, ASN, OD1 2.80Å
B, 575, TRP, HA A, 574, ASN, O 3.31Å
B, 578, GLY, HA1 A, 575, TRP, O 3.46Å
A, 571, TYR, HA B, 574, ASN, OD1 2.80Å
A, 575, TRP, HA B, 574, ASN, O 3.31Å
A, 578, GLY, HA1 B, 575, TRP, O 3.46Å