UniProt data
UniProt name: TM11B_HUMAN (Q86T26)
Gene name: TMPRSS11B; Synonyms=HATL5
Organism: Homo sapiens (Human).
Function: Serine protease. {ECO:0000269|PubMed:24498351}.
Subcellular location: Cell membrane {ECO:0000269|PubMed:24498351}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 18-38, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 416 AA
10 20 30 40 50 60
MYRHGISSQR SWPLWTTIFI FLGVAAILGV TIGLLVHFLA VEKTYYYQGD FHISGVTYND
70 80 90 100 110 120
NCENAASQAS TNLSKDIETK MLNAFQNSSI YKEYVKSEVI KLLPNANGSN VQLQLKFKFP
130 140 150 160 170 180
PAEGVSMRTK IKAKLHQMLK NNMASWNAVP ASIKLMEISK AASEMLTNNC CGRQVANSII
190 200 210 220 230 240
TGNKIVNGKS SLEGAWPWQA SMQWKGRHYC GASLISSRWL LSAAHCFAKK NNSKDWTVNF
250 260 270 280 290 300
GIVVNKPYMT RKVQNIIFHE NYSSPGLHDD IALVQLAEEV SFTEYIRKIC LPEAKMKLSE
310 320 330 340 350 360
NDNVVVTGWG TLYMNGSFPV ILQEDFLKII DNKICNASYA YSGFVTDTML CAGFMSGEAD
370 380 390 400 410
ACQNDSGGPL AYPDSRNIWH LVGIVSWGDG CGKKNKPGVY TRVTSYRNWI TSKTGL
CATM prediction
The sequence of TM11B_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 20 30 40 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | WTTIFIFLGVAAILGVTIGLLVHFLAV | 6.9 | -39.1° | 2.7 | 43.9 | -50.1 |
| Model 2 | WTTIFIFLGVAAILGVTIGLLVHFLAV | 6.6 | -53.0° | 4.2 | 54.1 | -37.5 |
| Model 3 | WTTIFIFLGVAAILGVTIGLLVHFLAV | 7.1 | -53.8° | 4.8 | 40.9 | -27.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 26, ALA, HA | A, 25, ALA, O | 3.03Å |
| B, 29, GLY, HA1 | A, 26, ALA, O | 3.04Å |
| B, 30, VAL, HA | A, 29, GLY, O | 3.32Å |
| A, 26, ALA, HA | B, 25, ALA, O | 3.03Å |
| A, 29, GLY, HA1 | B, 26, ALA, O | 3.04Å |
| A, 30, VAL, HA | B, 29, GLY, O | 3.32Å |
