Desmoglein-4

UniProt data

UniProt name: DSG4_HUMAN (Q86SJ6)

Gene name: DSG4; Synonyms=CDHF13

Organism: Homo sapiens (Human).

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, desmosome {ECO:0000250}.

Transmembrane domains:

  1. 632-652, 21 AA, Helical. {ECO:0000255}.

Sequence: 1040 AA

10 20 30 40 50 60 MDWLFFRNIC LLIILMVVME VNSEFIVEVK EFDIENGTTK WQTVRRQKRE WIKFAAACRE 70 80 90 100 110 120 GEDNSKRNPI AKIRSDCESN QKITYRISGV GIDRPPYGVF TINPRTGEIN ITSVVDREIT 130 140 150 160 170 180 PLFLIYCRAL NSRGEDLERP LELRVKVMDI NDNAPVFSQS VYTASIEENS DANTLVVKLC 190 200 210 220 230 240 ATDADEENHL NSKIAYKIVS QEPSGAPMFI LNRYTGEVCT MSSFLDREQH SMYNLVVRGS 250 260 270 280 290 300 DRDGAADGLS SECDCRIKVL DVNDNFPTLE KTSYSASIEE NCLSSELIRL QAIDLDEEGT 310 320 330 340 350 360 DNWLAQYLIL SGNDGNWFDI QTDPQTNEGI LKVVKMLDYE QAPNIQLSIG VKNQADFHYS 370 380 390 400 410 420 VASQFQMHPT PVRIQVVDVR EGPAFHPSTM AFSVREGIKG SSLLNYVLGT YTAIDLDTGN 430 440 450 460 470 480 PATDVRYIIG HDAGSWLKID SRTGEIQFSR EFDKKSKYII NGIYTAEILA IDDGSGKTAT 490 500 510 520 530 540 GTICIEVPDI NDYCPNIFPE RRTICIDSPS VLISVNEHSY GSPFTFCVVD EPPGIADMWD 550 560 570 580 590 600 VRSTNATSAI LTAKQVLSPG FYEIPILVKD SYNRACELAQ MVQLYACDCD DNHMCLDSGA 610 620 630 640 650 660 AGIYTEDITG DTYGPVTEDQ AGVSNVGLGP AGIGMMVLGI LLLILAPLLL LLCCCKQRQP 670 680 690 700 710 720 EGLGTRFAPV PEGGEGVMQS WRIEGAHPED RDVSNICAPM TASNTQDRMD SSEIYTNTYA 730 740 750 760 770 780 AGGTVEGGVS GVELNTGMGT AVGLMAAGAA GASGAARKRS STMGTLRDYA DADINMAFLD 790 800 810 820 830 840 SYFSEKAYAY ADEDEGRPAN DCLLIYDHEG VGSPVGSIGC CSWIVDDLDE SCMETLDPKF 850 860 870 880 890 900 RTLAEICLNT EIEPFPSHQA CIPISTDLPL LGPNYFVNES SGLTPSEVEF QEEMAASEPV 910 920 930 940 950 960 VHGDIIVTET YGNADPCVQP TTIIFDPQLA PNVVVTEAVM APVYDIQGNI CVPAELADYN 970 980 990 1000 1010 1020 NVIYAERVLA SPGVPDMSNS STTEGCMGPV MSGNILVGPE IQVMQMMSPD LPIGQTVGST 1030 SPMTSRHRVT RYSNIHYTQQ

CATM prediction

The sequence of DSG4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   630       640       650   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 GAAGIGMMVLGILLLILAALLLLLCCC 7.1 -48.0° 4.3 35.0 -9.2
Model 2 GAAGIGMMVLGILLLILAALLLLLCCC 7.1 -55.0° 4.2 37.9 -0.8
Prolines* GPAGIGMMVLGILLLILAPLLLLLCCC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session