Uncharacterized aarF domain-containing protein kinase 2

UniProt data

UniProt name: ADCK2_HUMAN (Q7Z695)

Gene name: ADCK2; Synonyms=AARF

Organism: Homo sapiens (Human).

Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 103-123, 21 AA, Helical. {ECO:0000255}.

Sequence: 626 AA

10 20 30 40 50 60 MVAPWRVSVR VCLSHLRCFE LRQGLSLLRP SECPRDARLC WLLLGTLPKV VSLCGDVGEG 70 80 90 100 110 120 APDVLSRRRV RCSGAAGAGP AESLPRAGPL GGVFLHLRLW LRAGALLVKF FPLLLLYPLT 130 140 150 160 170 180 YLAPSVSTLW LHLLLKATET SGPTYIKLGQ WASTRRDLFS EAFCAQFSKL HVRVTPHPWT 190 200 210 220 230 240 HTERFLRQAF GDDWGSILSF ENREPVGSGC VAQVYKAYAN TAFLETDSVQ RLGRASCLPP 250 260 270 280 290 300 FSHTGAVGGL RELFGYLGNG RKPPENLADQ SFLERLLLPK ADLVGSNAGV SRAQVPGHQP 310 320 330 340 350 360 EATNLISVAV KVLHPGLLAQ VHMDLLLMKI GSRVLGVLPG IKWLSLPEIV EEFEKLMVQQ 370 380 390 400 410 420 IDLRYEAQNL EHFQVNFRNV KAVKFPTPLR PFVTREVLVE TYEESVPVSS YQQAGIPVDL 430 440 450 460 470 480 KRKIARLGIN MLLKMIFVDN FVHADLHPGN ILVQGANGLS SSQEAQLQQA DICDTLVVAV 490 500 510 520 530 540 PSSLCPLRLV LLDAGIVAEL QAPDLRNFRA VFMAVVMGQG QRVAELILHH ARASECRDVE 550 560 570 580 590 600 GFKTEMAMLV TQARKNTITL EKLHVSSLLS SVFKLLMTHK VKLESNFASI VFAIMVLEGL 610 620 GRSLDPKLDI LEAARPFLLT GPVCPP

CATM prediction

The sequence of ADCK2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  100       110       120    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 WLRAGALLVKFFALLLLYALTYLAASV 7.4 -45.0° 4.0 39.0 -2.7
Prolines* WLRAGALLVKFFPLLLLYPLTYLAPSV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session