Protein RIC-3

UniProt data

UniProt name: RIC3_HUMAN (Q7Z5B4)

Gene name: RIC3; ORFNames=UNQ720/PRO1385

Organism: Homo sapiens (Human).

Function: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269|PubMed:12821669, ECO:0000269|PubMed:15504725, ECO:0000269|PubMed:15809299, ECO:0000269|PubMed:15927954, ECO:0000269|PubMed:16120769, ECO:0000269|PubMed:17609200, ECO:0000269|PubMed:18691158}.

Subcellular location: Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single- pass membrane protein.

Transmembrane domains:

  1. 96-116, 21 AA, Helical. {ECO:0000255}.

Sequence: 369 AA

10 20 30 40 50 60 MAYSTVQRVA LASGLVLALS LLLPKAFLSR GKRQEPPPTP EGKLGRFPPM MHHHQAPSDG 70 80 90 100 110 120 QTPGARFQRS HLAEAFAKAK GSGGGAGGGG SGRGLMGQII PIYGFGIFLY ILYILFKLSK 130 140 150 160 170 180 GKTTAEDGKC YTAMPGNTHR KITSFELAQL QEKLKETEAA MEKLINRVGP NGESRAQTVT 190 200 210 220 230 240 SDQEKRLLHQ LREITRVMKE GKFIDRFSPE KEAEEAPYME DWEGYPEETY PIYDLSDCIK 250 260 270 280 290 300 RRQETILVDY PDPKELSAEE IAERMGMIEE EESDHLGWES LPTDPRAQED NSVTSCDPKP 310 320 330 340 350 360 ETCSCCFHED EDPAVLAENA GFSADSYPEQ EETTKEEWSQ DFKDEGLGIS TDKAYTGSML RKRNPQGLE

CATM prediction

The sequence of RIC3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         100       110       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 RGLMGQIIAIYGFGIFLYILYILFKLS 7.1 -41.0° 3.5 38.0 -26.8
Model 2 RGLMGQIIAIYGFGIFLYILYILFKLS 7.3 -54.0° 3.6 35.0 -16.7
Prolines* RGLMGQIIPIYGFGIFLYILYILFKLS          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 98, GLN, HE21 A, 97, GLY, O 2.71Å
A, 98, GLN, HE21 B, 97, GLY, O 2.71Å