Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

UniProt data

UniProt name: GLTL5_HUMAN (Q7Z4T8)

Gene name: GALNTL5; Synonyms=GALNT15

Organism: Homo sapiens (Human).

Function: Probable inactive glycosyltransferase required during spermatid development. May participate in protein loading into the acrosomes and accumulation of ubiquitin-proteasome systems around the head-tail coupling apparatus region.

Subcellular location: Late endosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Localizes to the juxtanuclear region, possibly the late endosome. Not localized in the Golgi apparatus in round spermatids (By similarity). {ECO:0000250}.

Transmembrane domains:

  1. 5-27, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 443 AA

10 20 30 40 50 60 MRNAIIQGLF YGSLTFGIWT ALLFIYLHHN HVSSWQKKSQ EPLSAWSPGK KVHQQIIYGS 70 80 90 100 110 120 EQIPKPHVIV KRTDEDKAKS MLGTDFNHTN PELHKELLKY GFNVIISRSL GIEREVPDTR 130 140 150 160 170 180 SKMCLQKHYP ARLPTASIVI CFYNEECNAL FQTMSSVTNL TPHYFLEEII LVDDMSKVDD 190 200 210 220 230 240 LKEKLDYHLE TFRGKVKIIR NKKREGLIRA RLIGASHASG DVLVFLDSHC EVNRVWLEPL 250 260 270 280 290 300 LHAIAKDPKM VVCPLIDVID DRTLEYKPSP LVRGTFDWNL QFKWDNVFSY EMDGPEGSTK 310 320 330 340 350 360 PIRSPAMSGG IFAIRRHYFN EIGQYDKDMD FWGRENLELS LRIWMCGGQL FIIPCSRVGH 370 380 390 400 410 420 ISKKQTGKPS TIISAMTHNY LRLVHVWLDE YKEQFFLRKP GLKYVTYGNI RERVELRKRL 430 440 GCKSFQWYLD NVFPELEASV NSL

CATM prediction

The sequence of GLTL5_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          10        20        3
   +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 RNAIIQGLFYGSLTFGIWTALLFIYLHHN 6.7 -47.0° 1.3 45.2 -32.1
Model 2 RNAIIQGLFYGSLTFGIWTALLFIYLHHN 6.8 -51.0° 2.4 44.7 -23.5
Model 3 RNAIIQGLFYGSLTFGIWTALLFIYLHHN 7.2 -55.1° 0.9 49.9 -19.9
Model 4 RNAIIQGLFYGSLTFGIWTALLFIYLHHN 7.3 -34.0° 1.6 57.0 -15.5
Model 5 RNAIIQGLFYGSLTFGIWTALLFIYLHHN 7.3 -54.0° 3.6 49.0 -11.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 8, GLY, HA1 A, 5, ILE, O 2.63Å
B, 9, LEU, HA A, 8, GLY, O 2.91Å
A, 8, GLY, HA1 B, 5, ILE, O 2.63Å
A, 9, LEU, HA B, 8, GLY, O 2.91Å