Low-density lipoprotein receptor-related protein 10

UniProt data

UniProt name: LRP10_HUMAN (Q7Z4F1)

Gene name: LRP10; ORFNames=MSTP087, SP220, UNQ389/PRO724

Organism: Homo sapiens (Human).

Function: Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Membrane, coated pit {ECO:0000250}.

Transmembrane domains:

  1. 441-461, 21 AA, Helical. {ECO:0000255}.

Sequence: 713 AA

10 20 30 40 50 60 MLLATLLLLL LGGALAHPDR IIFPNHACED PPAVLLEVQG TLQRPLVRDS RTSPANCTWL 70 80 90 100 110 120 ILGSKEQTVT IRFQKLHLAC GSERLTLRSP LQPLISLCEA PPSPLQLPGG NVTITYSYAG 130 140 150 160 170 180 ARAPMGQGFL LSYSQDWLMC LQEEFQCLNH RCVSAVQRCD GVDACGDGSD EAGCSSDPFP 190 200 210 220 230 240 GLTPRPVPSL PCNVTLEDFY GVFSSPGYTH LASVSHPQSC HWLLDPHDGR RLAVRFTALD 250 260 270 280 290 300 LGFGDAVHVY DGPGPPESSR LLRSLTHFSN GKAVTVETLS GQAVVSYHTV AWSNGRGFNA 310 320 330 340 350 360 TYHVRGYCLP WDRPCGLGSG LGAGEGLGER CYSEAQRCDG SWDCADGTDE EDCPGCPPGH 370 380 390 400 410 420 FPCGAAGTSG ATACYLPADR CNYQTFCADG ADERRCRHCQ PGNFRCRDEK CVYETWVCDG 430 440 450 460 470 480 QPDCADGSDE WDCSYVLPRK VITAAVIGSL VCGLLLVIAL GCTCKLYAIR TQEYSIFAPL 490 500 510 520 530 540 SRMEAEIVQQ QAPPSYGQLI AQGAIPPVED FPTENPNDNS VLGNLRSLLQ ILRQDMTPGG 550 560 570 580 590 600 GPGARRRQRG RLMRRLVRRL RRWGLLPRTN TPARASEARS QVTPSAAPLE ALDGGTGPAR 610 620 630 640 650 660 EGGAVGGQDG EQAPPLPIKA PLPSASTSPA PTTVPEAPGP LPSLPLEPSL LSGVVQALRG 670 680 690 700 710 RLLPSLGPPG PTRSPPGPHT AVLALEDEDD VLLVPLAEPG VWVAEAEDEP LLT

CATM prediction

The sequence of LRP10_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    440       450       460  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 ARKVITAAVIGSLVCGLLLVIALGCTC 6.7 -50.0° 2.9 46.8 -16.9
Prolines* PRKVITAAVIGSLVCGLLLVIALGCTC          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 445, ALA, HA A, 444, ALA, O 2.73Å
B, 448, GLY, HA1 A, 445, ALA, O 2.70Å
A, 445, ALA, HA B, 444, ALA, O 2.73Å
A, 448, GLY, HA1 B, 445, ALA, O 2.70Å