Transmembrane protease serine 9

UniProt data

UniProt name: TMPS9_HUMAN (Q7Z410)

Gene name: TMPRSS9

Organism: Homo sapiens (Human).

Function: Serase-1 and serase-2 are serine proteases that hydrolyze the peptides N-t-Boc-Gln-Ala-Arg-AMC and N-t-Boc-Gln- Gly-Arg-AMC. In contrast, N-t-Boc-Ala-Phe-Lys-AMC and N-t-Boc-Ala- Pro-Ala-AMC are not significantly hydrolyzed.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12886014}; Single-pass type II membrane protein {ECO:0000269|PubMed:12886014}.

Transmembrane domains:

  1. 30-50, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 1059 AA

10 20 30 40 50 60 MEPTVADVHL VPRTTKEVPA LDAACCRAAS IGVVATSLVV LTLGVLLAFL STQGFHVDHT 70 80 90 100 110 120 AELRGIRWTS SLRRETSDYH RTLTPTLEAL LHFLLRPLQT LSLGLEEELL QRGIRARLRE 130 140 150 160 170 180 HGISLAAYGT IVSAELTGRH KGPLAERDFK SGRCPGNSFS CGNSQCVTKV NPECDDQEDC 190 200 210 220 230 240 SDGSDEAHCE CGLQPAWRMA GRIVGGMEAS PGEFPWQASL RENKEHFCGA AIINARWLVS 250 260 270 280 290 300 AAHCFNEFQD PTKWVAYVGA TYLSGSEAST VRAQVVQIVK HPLYNADTAD FDVAVLELTS 310 320 330 340 350 360 PLPFGRHIQP VCLPAATHIF PPSKKCLISG WGYLKEDFLV KPEVLQKATV ELLDQALCAS 370 380 390 400 410 420 LYGHSLTDRM VCAGYLDGKV DSCQGDSGGP LVCEEPSGRF FLAGIVSWGI GCAEARRPGV 430 440 450 460 470 480 YARVTRLRDW ILEATTKASM PLAPTMAPAP AAPSTAWPTS PESPVVSTPT KSMQALSTVP 490 500 510 520 530 540 LDWVTVPKLQ ECGARPAMEK PTRVVGGFGA ASGEVPWQVS LKEGSRHFCG ATVVGDRWLL 550 560 570 580 590 600 SAAHCFNHTK VEQVRAHLGT ASLLGLGGSP VKIGLRRVVL HPLYNPGILD FDLAVLELAS 610 620 630 640 650 660 PLAFNKYIQP VCLPLAIQKF PVGRKCMISG WGNTQEGNAT KPELLQKASV GIIDQKTCSV 670 680 690 700 710 720 LYNFSLTDRM ICAGFLEGKV DSCQGDSGGP LACEEAPGVF YLAGIVSWGI GCAQVKKPGV 730 740 750 760 770 780 YTRITRLKGW ILEIMSSQPL PMSPPSTTRM LATTSPRTTA GLTVPGATPS RPTPGAASRV 790 800 810 820 830 840 TGQPANSTLS AVSTTARGQT PFPDAPEATT HTQLPDCGLA PAALTRIVGG SAAGRGEWPW 850 860 870 880 890 900 QVSLWLRRRE HRCGAVLVAE RWLLSAAHCF DVYGDPKQWA AFLGTPFLSG AEGQLERVAR 910 920 930 940 950 960 IYKHPFYNLY TLDYDVALLE LAGPVRRSRL VRPICLPEPA PRPPDGTRCV ITGWGSVREG 970 980 990 1000 1010 1020 GSMARQLQKA AVRLLSEQTC RRFYPVQISS RMLCAGFPQG GVDSCSGDAG GPLACREPSG 1030 1040 1050 RWVLTGVTSW GYGCGRPHFP GVYTRVAAVR GWIGQHIQE

CATM prediction

The sequence of TMPS9_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     30        40        50  
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 RAASIGVVATSLVVLTLGVLLAFLSTQ 7.2 -43.8° 1.8 45.1 -24.6
Model 2 RAASIGVVATSLVVLTLGVLLAFLSTQ 7.3 -40.0° 4.0 38.0 -2.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 41, LEU, HA A, 40, VAL, O 3.37Å
B, 44, GLY, HA1 A, 41, LEU, O 3.16Å
B, 45, VAL, HA A, 44, GLY, O 3.43Å
A, 41, LEU, HA B, 40, VAL, O 3.37Å
A, 44, GLY, HA1 B, 41, LEU, O 3.16Å
A, 45, VAL, HA B, 44, GLY, O 3.43Å