Synaptotagmin-13

UniProt data

UniProt name: SYT13_HUMAN (Q7L8C5)

Gene name: SYT13; Synonyms=KIAA1427

Organism: Homo sapiens (Human).

Function: May be involved in transport vesicle docking to the plasma membrane. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 7-29, 23 AA, Helical. {ECO:0000255}.

Sequence: 426 AA

10 20 30 40 50 60 MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK AKPSLLGSAQ 70 80 90 100 110 120 QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY SLRSTEEPTA PASPQPPNDS 130 140 150 160 170 180 RLKRQVTEEL FILPQNGVVE DVCVMETWNP EKAASWNQAP KLHYCLDYDC QKAELFVTRL 190 200 210 220 230 240 EAVTSNHDGG CDCYVQGSVA NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT 250 260 270 280 290 300 LTLRTCDRFS RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA 310 320 330 340 350 360 ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH KINPVWNEMI 370 380 390 400 410 420 MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS GSERSHWEEM LKNPRRQIAM WHQLHL

CATM prediction

The sequence of SYT13_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        10        20        30 
 +    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 SVAVIALGATLGTATSILALCGVTCLCRH 6.5 -53.9° 3.6 48.7 -23.4
Model 2 SVAVIALGATLGTATSILALCGVTCLCRH 7.2 -46.5° 2.7 47.0 -6.6
Prolines* SVPVIALGATLGTATSILALCGVTCLCRH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 11, GLY, HA1 A, 8, ILE, O 3.02Å
B, 12, ALA, HA A, 11, GLY, O 2.37Å
B, 12, ALA, HA A, 12, ALA, O 3.40Å
B, 15, GLY, HA1 A, 12, ALA, O 2.87Å
A, 11, GLY, HA1 B, 8, ILE, O 3.02Å
A, 12, ALA, HA B, 11, GLY, O 2.37Å
A, 12, ALA, HA B, 12, ALA, O 3.40Å
A, 15, GLY, HA1 B, 12, ALA, O 2.87Å