Serine/threonine-protein kinase/endoribonuclease IRE2

UniProt data

UniProt name: ERN2_HUMAN (Q76MJ5)

Gene name: ERN2 {ECO:0000312|HGNC:HGNC:16942}

Organism: Homo sapiens (Human).

Function: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. {ECO:0000269|PubMed:11175748}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11175748}; Single-pass type I membrane protein {ECO:0000269|PubMed:11175748}.

Transmembrane domains:

  1. 431-451, 21 AA, Helical. {ECO:0000255}.

Sequence: 926 AA

10 20 30 40 50 60 MASAVRGSRP WPRLGLQLQF AALLLGTLSP QVHTLRPENL LLVSTLDGSL HALSKQTGDL 70 80 90 100 110 120 KWTLRDDPVI EGPMYVTEMA FLSDPADGSL YILGTQKQQG LMKLPFTIPE LVHASPCRSS 130 140 150 160 170 180 DGVFYTGRKQ DAWFVVDPES GETQMTLTTE GPSTPRLYIG RTQYTVTMHD PRAPALRWNT 190 200 210 220 230 240 TYRRYSAPPM DGSPGKYMSH LASCGMGLLL TVDPGSGTVL WTQDLGVPVM GVYTWHQDGL 250 260 270 280 290 300 RQLPHLTLAR DTLHFLALRW GHIRLPASGP RDTATLFSTL DTQLLMTLYV GKDETGFYVS 310 320 330 340 350 360 KALVHTGVAL VPRGLTLAPA DGPTTDEVTL QVSGEREGSP STAVRYPSGS VALPSQWLLI 370 380 390 400 410 420 GHHELPPVLH TTMLRVHPTL GSGTAETRPP ENTQAPAFFL ELLSLSREKL WDSELHPEEK 430 440 450 460 470 480 TPDSYLGLGP QDLLAASLTA VLLGGWILFV MRQQQPQVVE KQQETPLAPA DFAHISQDAQ 490 500 510 520 530 540 SLHSGASRRS QKRLQSPSKQ AQPLDDPEAE QLTVVGKISF NPKDVLGRGA GGTFVFRGQF 550 560 570 580 590 600 EGRAVAVKRL LRECFGLVRR EVQLLQESDR HPNVLRYFCT ERGPQFHYIA LELCRASLQE 610 620 630 640 650 660 YVENPDLDRG GLEPEVVLQQ LMSGLAHLHS LHIVHRDLKP GNILITGPDS QGLGRVVLSD 670 680 690 700 710 720 FGLCKKLPAG RCSFSLHSGI PGTEGWMAPE LLQLLPPDSP TSAVDIFSAG CVFYYVLSGG 730 740 750 760 770 780 SHPFGDSLYR QANILTGAPC LAHLEEEVHD KVVARDLVGA MLSPLPQPRP SAPQVLAHPF 790 800 810 820 830 840 FWSRAKQLQF FQDVSDWLEK ESEQEPLVRA LEAGGCAVVR DNWHEHISMP LQTDLRKFRS 850 860 870 880 890 900 YKGTSVRDLL RAVRNKKHHY RELPVEVRQA LGQVPDGFVQ YFTNRFPRLL LHTHRAMRSC 910 920 ASESLFLPYY PPDSEARRPC PGATGR

CATM prediction

The sequence of ERN2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    430       440       450  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LGAQDLLAASLTAVLLGGWILFVMRQQ 7.4 -54.0° 3.6 48.8 -1.2
Prolines* LGPQDLLAASLTAVLLGGWILFVMRQQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 441, VAL, HA A, 440, ALA, O 3.33Å
B, 444, GLY, HA1 A, 441, VAL, O 3.48Å
A, 441, VAL, HA B, 440, ALA, O 3.33Å
A, 444, GLY, HA1 B, 441, VAL, O 3.48Å