Inhibitor of nuclear factor kappa-B kinase-interacting protein

UniProt data

UniProt name: IKIP_HUMAN (Q70UQ0)

Gene name: IKBIP; Synonyms=IKIP

Organism: Homo sapiens (Human).

Function: Target of p53/TP53 with pro-apoptotic function. {ECO:0000269|PubMed:15389287}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15389287}; Single-pass membrane protein {ECO:0000269|PubMed:15389287}. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.

Transmembrane domains:

  1. 46-62, 17 AA, Helical. {ECO:0000255}.

Sequence: 350 AA

10 20 30 40 50 60 MSEVKSRKKS GPKGAPAAEP GKRSEGGKTP VARSSGGGGW ADPRTCLSLL SLGTCLGLAW 70 80 90 100 110 120 FVFQQSEKFA KVENQYQLLK LETNEFQQLQ SKISLISEKW QKSEAIMEQL KSFQIIAHLK 130 140 150 160 170 180 RLQEEINEVK TWSNRITEKQ DILNNSLTTL SQDITKVDQS TTSMAKDVGL KITSVKTDIR 190 200 210 220 230 240 RISGLVTDVI SLTDSVQELE NKIEKVEKNT VKNIGDLLSS SIDRTATLRK TASENSQRIN 250 260 270 280 290 300 SVKKTLTELK SDFDKHTDRF LSLEGDRAKV LKTVTFANDL KPKVYNLKKD FSRLEPLVND 310 320 330 340 LTLRIGRLVT DLLQREKEIA FLSEKISNLT IVQAEIKDIK DEIAHISDMN

CATM prediction

The sequence of IKIP_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         50        60    
  +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 ARTCLSLLSLGTCLGLAWFVFQQ 7.3 -47.8° 0.7 54.0 -24.7
Prolines* PRTCLSLLSLGTCLGLAWFVFQQ          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 53, GLY, HA1 A, 50, LEU, O 3.38Å
B, 54, THR, HA A, 53, GLY, O 3.47Å
A, 53, GLY, HA1 B, 50, LEU, O 3.38Å
A, 54, THR, HA B, 53, GLY, O 3.47Å