UniProt data
UniProt name: TM11F_HUMAN (Q6ZWK6)
Gene name: TMPRSS11F; Synonyms=HATL4
Organism: Homo sapiens (Human).
Function: Probable serine protease. {ECO:0000250}.
Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Transmembrane domains:
- 33-53, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 438 AA
10 20 30 40 50 60
MMYAPVEFSE AEFSRAEYQR KQQFWDSVRL ALFTLAIVAI IGIAIGIVTH FVVEDDKSFY
70 80 90 100 110 120
YLASFKVTNI KYKENYGIRS SREFIERSHQ IERMMSRIFR HSSVGGRFIK SHVIKLSPDE
130 140 150 160 170 180
QGVDILIVLI FRYPSTDSAE QIKKKIEKAL YQSLKTKQLS LTINKPSFRL TPIDSKKMRN
190 200 210 220 230 240
LLNSRCGIRM TSSNMPLPAS SSTQRIVQGR ETAMEGEWPW QASLQLIGSG HQCGASLISN
250 260 270 280 290 300
TWLLTAAHCF WKNKDPTQWI ATFGATITPP AVKRNVRKII LHENYHRETN ENDIALVQLS
310 320 330 340 350 360
TGVEFSNIVQ RVCLPDSSIK LPPKTSVFVT GFGSIVDDGP IQNTLRQARV ETISTDVCNR
370 380 390 400 410 420
KDVYDGLITP GMLCAGFMEG KIDACKGDSG GPLVYDNHDI WYIVGIVSWG QSCALPKKPG
430
VYTRVTKYRD WIASKTGM
CATM prediction
The sequence of TM11F_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 30 40 50 | + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | LALFTLAIVAIIGIAIGIVTHFVVEDD | 6.6 | -49.1° | 4.5 | 48.7 | -20.9 |
| Model 2 | LALFTLAIVAIIGIAIGIVTHFVVEDD | 7.3 | -54.0° | 3.6 | 35.5 | -7.2 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 42, GLY, HA1 | A, 39, ALA, O | 3.37Å |
| B, 43, ILE, HA | A, 42, GLY, O | 2.54Å |
| B, 46, GLY, HA1 | A, 43, ILE, O | 2.93Å |
| A, 42, GLY, HA1 | B, 39, ALA, O | 3.37Å |
| A, 43, ILE, HA | B, 42, GLY, O | 2.54Å |
| A, 46, GLY, HA1 | B, 43, ILE, O | 2.93Å |
