Patatin-like phospholipase domain-containing protein 7

UniProt data

UniProt name: PLPL7_HUMAN (Q6ZV29)

Gene name: PNPLA7; Synonyms=C9orf111

Organism: Homo sapiens (Human).

Function: Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Mitochondrion membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Found in the nuclear, mitochondrial, lysosomal, and microsomal fractions. {ECO:0000250}.

Transmembrane domains:

  1. 13-33, 21 AA, Helical. {ECO:0000255}.

Sequence: 1317 AA

10 20 30 40 50 60 MEEEKDDSPQ LTGIAVGALL ALALVGVLIL FMFRRLRQFR QAQPTPQYRF RKRDKVMFYG 70 80 90 100 110 120 RKIMRKVTTL PNTLVENTAL PRQRARKRTK VLSLAKRILR FKKEYPALQP KEPPPSLLEA 130 140 150 160 170 180 DLTEFDVKNS HLPSEVLYML KNVRVLGHFE KPLFLELCKH IVFVQLQEGE HVFQPREPDP 190 200 210 220 230 240 SICVVQDGRL EVCIQDTDGT EVVVKEVLAG DSVHSLLSIL DIITGHAAPY KTVSVRAAIP 250 260 270 280 290 300 STILRLPAAA FHGVFEKYPE TLVRVVQIIM VRLQRVTFLA LHNYLGLTTE LFNAESQAIP 310 320 330 340 350 360 LVSVASVAAG KAKKQVFYGE EERLKKPPRL QESCDSDHGG GRPAAAGPLL KRSHSVPAPS 370 380 390 400 410 420 IRKQILEELE KPGAGDPDPS APQGGPGSAT SDLGMACDRA RVFLHSDEHP GSSVASKSRK 430 440 450 460 470 480 SVMVAEIPST VSQHSESHTD ETLASRKSDA IFRAAKKDLL TLMKLEDSSL LDGRVALLHV 490 500 510 520 530 540 PAGTVVSRQG DQDASILFVV SGLLHVYQRK IGSQEDTCLF LTRPGEMVGQ LAVLTGEPLI 550 560 570 580 590 600 FTVKANRDCS FLSISKAHFY EIMRKQPTVV LGVAHTVVKR MSSFVRQIDF ALDWVEVEAG 610 620 630 640 650 660 RAIYRQGDKS DCTYIMLSGR LRSVIRKDDG KKRLAGEYGR GDLVGVVETL THQARATTVH 670 680 690 700 710 720 AVRDSELAKL PAGALTSIKR RYPQVVTRLI HLLGEKILGS LQQGPVTGHQ LGLPTEGSKW 730 740 750 760 770 780 DLGNPAVNLS TVAVMPVSEE VPLTAFALEL EHALSAIGPT LLLTSDNIKR RLGSAALDSV 790 800 810 820 830 840 HEYRLSSWLG QQEDTHRIVL YQVDGTLTPW TQRCVRQADC ILIVGLGDQE PTVGELERML 850 860 870 880 890 900 ESTAVRAQKQ LILLHREEGP APARTVEWLN MRSWCSGHLH LCCPRRVFSR RSLPKLVEMY 910 920 930 940 950 960 KHVFQRPPDR HSDFSRLARV LTGNAIALVL GGGGARGCAQ VGVLKALAEC GIPVDMVGGT 970 980 990 1000 1010 1020 SIGAFVGALY SEERNYSQMR IRAKQWAEGM TSLMKAALDL TYPITSMFSG AGFNSSIFSV 1030 1040 1050 1060 1070 1080 FKDQQIEDLW IPYFAITTDI TASAMRVHTD GSLWWYVRAS MSLSGYMPPL CDPKDGHLLM 1090 1100 1110 1120 1130 1140 DGGYINNLPA DVARSMGAKV VIAIDVGSRD ETDLTNYGDA LSGWWLLWKR WNPLATKVKV 1150 1160 1170 1180 1190 1200 LNMAEIQTRL AYVCCVRQLE VVKSSDYCEY LRPPIDSYST LDFGKFNEIC EVGYQHGRTV 1210 1220 1230 1240 1250 1260 FDIWGRSGVL EKMLRDQQGP SKKPASAVLT CPNASFTDLA EIVSRIEPAK PAMVDDESDY 1270 1280 1290 1300 1310 QTEYEEELLD VPRDAYADFQ STSAQQGSDL EDESSLRHRH PSLAFPKLSE GSSDQDG

CATM prediction

The sequence of PLPL7_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  10        20        30     
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 QLTGIAVGALLALALVGVLILFMFRRL 6.8 -44.2° 1.8 45.1 -23.6
Model 2 QLTGIAVGALLALALVGVLILFMFRRL 7.3 -27.0° 6.0 58.0 -20.3
Model 3 QLTGIAVGALLALALVGVLILFMFRRL 6.4 -41.9° 6.0 58.1 -15.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 14, ILE, HA A, 13, GLY, O 3.00Å
B, 17, GLY, HA1 A, 14, ILE, O 2.79Å
B, 18, ALA, HA A, 17, GLY, O 3.16Å
A, 14, ILE, HA B, 13, GLY, O 3.00Å
A, 17, GLY, HA1 B, 14, ILE, O 2.79Å
A, 18, ALA, HA B, 17, GLY, O 3.16Å