Cilia- and flagella-associated protein 65 {ECO:0000305}

UniProt data

UniProt name: CFA65_HUMAN (Q6ZU64)

Gene name: CFAP65 {ECO:0000312|HGNC:HGNC:25325}

Organism: Homo sapiens (Human).

Function: May play a role in sperm motility. {ECO:0000250|UniProtKB:I6WQT8}.

Subcellular location: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:A8JFU2}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 188-208, 21 AA, Helical. {ECO:0000255}.

Sequence: 1925 AA

10 20 30 40 50 60 MFTLTGCRLV EKTQKVENPS VSFASSFPLI PLLLRGKSVQ KKQAESKSQI KLHTQSAPFG 70 80 90 100 110 120 LCPKDMMLTQ APSSVVRSRN SRNHTVNSGG SCLSASTVAI PAINDSSAAM SACSTISAQP 130 140 150 160 170 180 ASSMDTQMHS PKKQERVNKR VIWGIEVAEE LHWKGWELGK ETTRNLVLKN RSLKLQKMKY 190 200 210 220 230 240 RPPKTKFFFT VIPQPIFLSP GITLTLPIVF RPLEAKEYMD QLWFEKAEGM FCVGLRATLP 250 260 270 280 290 300 CHRLICRPPS LQLPMCAVGD TTEAFFCLDN VGDLPTFFTW EFSSPFQMLP ATGLLEPGQA 310 320 330 340 350 360 SQIKVTFQPL TAVIYEVQAT CWYGAGSRQR SSIQLQAVAK CAQLLVSIKH KCPEDQDAEG 370 380 390 400 410 420 FQKLLYFGSV AVGCTSERQI RLHNPSAVNA PFRIEISPDE LAEDQAFSCP TAHGIVLPGE 430 440 450 460 470 480 KKCVSVFFHP KTLDTRTVDY CSIMPSGCAS KTLLKVVGFC RGPAVSLQHY CVNFSWVNLG 490 500 510 520 530 540 ERSEQPLWIE NQSDCTAHFQ FAIDCLESVF TIRPAFGTLV GKARMTLHCA FQPTHPIICF 550 560 570 580 590 600 RRVACLIHHQ DPLFLDLMGT CHSDSTKPAI LKPQHLTWYR THLARGLTLY PPDILDAMLK 610 620 630 640 650 660 EKKLAQDQNG ALMIPIQDLE DMPAPQYPYI PPMTEFFFDG TSDITIFPPP ISVEPVEVDF 670 680 690 700 710 720 GACPGPEAPN PVPLCLMNHT KGKIMVVWTR RSDCPFWVTP ESCDVPPLKS MAMRLHFQPP 730 740 750 760 770 780 HPNCLYTVEL EAFAIYKVLQ SYSNIEEDCT MCPSWCLTVR ARGHSYFAGF EHHIPQYSLD 790 800 810 820 830 840 VPKLFPAVSS GEPTYRSLLL VNKDCKLLTF SLAPQRGSDV ILRPTSGLVA PGAHQIILIC 850 860 870 880 890 900 TYPEGSSWKQ HTFYLQCNAS PQYLKEVSMY SREEPLQLKL DTHKSLYFKP TWVGCSSTSP 910 920 930 940 950 960 FTFRNPSRLP LQFEWRVSEQ HRKLLAVQPS RGLIQPNERL TLTWTFSPLE ETKYLFQVGM 970 980 990 1000 1010 1020 WVWEAGLSPN ANPAATTHYM LRLVGVGLTS SLSAKEKELA FGNVLVNSKQ SRFLVLLNDG 1030 1040 1050 1060 1070 1080 NCTLYYRLYL EQGSPEAVDN HPLALQLDRT EGSMPPRSQD TICLTACPKQ RSQYSWTITY 1090 1100 1110 1120 1130 1140 SLLSHRDNKA GEKQELCCVS LVAVYPLLSI LDVSSMGSAE GITRKHLWRL FSLDLLNSYL 1150 1160 1170 1180 1190 1200 ERDPTPCELT YKVPTRHSMS QIPPVLTPLR LDFNFGAAPF KAPPSVVFLA LKNSGVVSLD 1210 1220 1230 1240 1250 1260 WAFLLPSDQR IDVELWAEQA ELNSTELHQM RVQDNCLFSI SPKAGSLSPG QEQMVELKYS 1270 1280 1290 1300 1310 1320 HLFIGTDHLP VLFKVSHGRE ILLNFIGVTV KPEQKYVHFT STTHQFIPIP IGDTLPPRQI 1330 1340 1350 1360 1370 1380 YELYNGGSVP VTYEVQTDVL SQVQEKNFDH PIFCCLNPKG EIQPGSTARV LWIFSPIEAK 1390 1400 1410 1420 1430 1440 TYTVDVPIHI LGWNSALIHF QGVGYNPHMM GDTAPFHNIS SWDNSSIHSR LVVPGQNVFL 1450 1460 1470 1480 1490 1500 SQSHISLGNI PVQSKCSRLL FLNNISKNEE IAFSWQPSPL DFGEVSVSPM IGVVAPEETV 1510 1520 1530 1540 1550 1560 PFVVTLRASV HASFYSADLV CKLYSQQLMR QYHKELQEWK DEKVRQEVEF TITDMKVKKR 1570 1580 1590 1600 1610 1620 TCCTACEPAR KYKTLPPIKN QQSVSRPASW KLQTPKEEVS WPCPQPPSPG MLCLGLTARA 1630 1640 1650 1660 1670 1680 HATDYFLANF FSEFPCHFLH RELPKRKAPR EESETSEEKS PNKWGPVSKQ KKQLLVDILT 1690 1700 1710 1720 1730 1740 TIIRGLLEDK NFHEAVDQSL VEQVPYFRQF WNEQSTKFMD QKNSLYLMPI LPVPSSSWED 1750 1760 1770 1780 1790 1800 GKGKQPKEDR PEHYPGLGKK EEGEEEKGEE EEEELEEEEE EEEETEEEEL GKEEIEEKEE 1810 1820 1830 1840 1850 1860 ERDEKEEKVS WAGIGPTPQP ESQESMQWQW QQQLNVMVKE EQEQDEKEAI RRLPAFANLQ 1870 1880 1890 1900 1910 1920 EALLENMIQN ILVEASRGEV VLTSRPRVIA LPPFCVPRSL TPDTLLPTQQ AEVLHPVVPL PTDLP

CATM prediction

The sequence of CFA65_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       190       200       21
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 TKFFFTVIAQAIFLSAGITLTLAIVFR 7.3 -40.8° 3.4 38.2 -23.2
Prolines* TKFFFTVIPQPIFLSPGITLTLPIVFR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 198, LEU, HA A, 197, PHE, O 3.30Å
B, 201, GLY, HA1 A, 198, LEU, O 3.34Å
B, 202, ILE, HA A, 205, THR, OG1 2.57Å
A, 198, LEU, HA B, 197, PHE, O 3.30Å
A, 201, GLY, HA1 B, 198, LEU, O 3.34Å
A, 202, ILE, HA B, 205, THR, OG1 2.57Å