Leucine-rich repeat-containing protein 55

UniProt data

UniProt name: LRC55_HUMAN (Q6ZSA7)

Gene name: LRRC55

Organism: Homo sapiens (Human).

Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269|PubMed:22547800}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 272-292, 21 AA, Helical. {ECO:0000255}.

Sequence: 311 AA

10 20 30 40 50 60 MGSLQHCCCL LPKMGDTWAQ LPWPGPPHPA MLLISLLLAA GLMHSDAGTS CPVLCTCRNQ 70 80 90 100 110 120 VVDCSSQRLF SVPPDLPMDT RNLSLAHNRI TAVPPGYLTC YMELQVLDLH NNSLMELPRG 130 140 150 160 170 180 LFLHAKRLAH LDLSYNNFSH VPADMFQEAH GLVHIDLSHN PWLRRVHPQA FQGLMQLRDL 190 200 210 220 230 240 DLSYGGLAFL SLEALEGLPG LVTLQIGGNP WVCGCTMEPL LKWLRNRIQR CTADSQLAEC 250 260 270 280 290 300 RGPPEVEGAP LFSLTEESFK ACHLTLTLDD YLFIAFVGFV VSIASVATNF LLGITANCCH 310 RWSKASEEEE I

CATM prediction

The sequence of LRC55_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
   270       280       290   
 |    +    |    +    |    +		 (Å) (°) (Å) (°)  
Model 1 DDYLFIAFVGFVVSIASVATNFLLGIT 7.2 -44.0° 1.8 45.0 -24.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 275, ALA, HA A, 274, ILE, O 3.40Å
B, 278, GLY, HA1 A, 275, ALA, O 3.19Å
B, 279, PHE, HA A, 278, GLY, O 3.45Å
B, 282, SER, HG1 A, 279, PHE, O 2.53Å
A, 275, ALA, HA B, 274, ILE, O 3.40Å
A, 278, GLY, HA1 B, 275, ALA, O 3.19Å
A, 279, PHE, HA B, 278, GLY, O 3.45Å
A, 282, SER, HG1 B, 279, PHE, O 2.53Å