Regulator of G-protein signaling 9-binding protein

UniProt data

UniProt name: R9BP_HUMAN (Q6ZS82)

Gene name: RGS9BP; Synonyms=R9AP

Organism: Homo sapiens (Human).

Function: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 211-231, 21 AA, Helical; Anchor for type IV membrane protein. {ECO:0000255}.

Sequence: 235 AA

10 20 30 40 50 60 MAREECKALL DGLNKTTACY HHLVLTVGGS ADSQNLRQEL QKTRQKAQEL AVSTCARLTA 70 80 90 100 110 120 VLRDRGLAAD ERAEFERLWV AFSGCLDLLE ADMRRALELG AAFPLHAPRR PLVRTGVAGA 130 140 150 160 170 180 SSGVAARALS TRSLRLEAEG DFDVADLREL EREVLQVGEM IDNMEMKVNV PRWTVQARQA 190 200 210 220 230 AGAELLSTVS AGPSSVVSLQ ERGGGCDPRK ALAAILFGAV LLAAVALAVC VAKLS

CATM prediction

The sequence of R9BP_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    210       220       230  
  |    +    |    +    |    
(Å) (°) (Å) (°)  
ARKALAAILFGAVLLAAVALAVCVAKL 7.3 -51.0° 4.3 40.5 -3.9
PRKALAAILFGAVLLAAVALAVCVAKL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 215, ILE, HA A, 214, ALA, O 3.25Å
B, 218, GLY, HA1 A, 215, ILE, O 3.49Å
A, 215, ILE, HA B, 214, ALA, O 3.25Å
A, 218, GLY, HA1 B, 215, ILE, O 3.49Å