Colorectal cancer-associated protein 1

UniProt data

UniProt name: COLC1_HUMAN (Q6ZS62)

Gene name: COLCA1; Synonyms=C11orf92

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000269|PubMed:24154973}; Single-pass membrane protein {ECO:0000269|PubMed:24154973}. Note=Co-localizes with crystalloid granules of eosinophils and granular organelles of mast cells, neutrophils, macrophages and dendritic cells.

Transmembrane domains:

  1. 77-97, 21 AA, Helical. {ECO:0000255}.

Sequence: 124 AA

10 20 30 40 50 60 MESCSVAQAG VLTSPFMWRW TGMAGALSAL DNTIEDDADD QLPCGEGRPG WVRGELLGSQ 70 80 90 100 110 120 GVCKDSKDLF VPTSSSLYGC FCVGLVSGMA ISVLLLASDF RKLDFSRPEP CFEKEASLWF VAQH

CATM prediction

The sequence of COLC1_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        80        90        1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 SSSLYGCFCVGLVSGMAISVLLLASDF 6.8 -38.0° 0.4 56.0 -36.0
Model 2 SSSLYGCFCVGLVSGMAISVLLLASDF 6.6 -54.0° 3.0 62.1 -10.1
Model 3 SSSLYGCFCVGLVSGMAISVLLLASDF 7.3 -43.0° 4.5 35.0 -9.8
Model 4 SSSLYGCFCVGLVSGMAISVLLLASDF 7.2 -54.7° 2.4 48.1 -2.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 81, PHE, HA A, 80, CYS, O 3.09Å
B, 84, GLY, HA1 A, 81, PHE, O 2.98Å
B, 85, LEU, HA A, 84, GLY, O 2.86Å
A, 81, PHE, HA B, 80, CYS, O 3.09Å
A, 84, GLY, HA1 B, 81, PHE, O 2.98Å
A, 85, LEU, HA B, 84, GLY, O 2.86Å